The significance of anterior prostate lesions on multiparametric magnetic resonance imaging in African-American men

Urologic Oncology
Michael KongnyuyPeter A Pinto

Abstract

African-American (AA) men tend to harbor high-risk prostate cancer (PCa) and exhibit worse outcomes when compared to other groups. It has been postulated that AA men may harbor more anterior prostate lesions (APLs) that are undersampled by the standard transrectal ultrasound guided-biopsy (SBx), potentially resulting in greater degree of Gleason score (GS) upgrading at radical prostatectomy. We aimed to evaluate the detection rate of anterior PCa significance of APLs in AA men on multiparametric magnetic resonance imaging (mpMRI) and compare it to a matched cohort of White/Other (W/O) men. A review of 1,267 men who had an mpMRI with suspicious prostate lesions and who underwent magnetic resonance transrectal ultrasound fusion-guided biopsy (FBx) with concurrent SBx in the same biopsy session was performed. All AA men were matched to a control group of W/O using a 1:1 propensity score-matching algorithm with age, prostate-specific antigen, and prostate volume as matching variables. Logistic regression analysis was used to determine predictors of APLs in AA men. Of the 195 AA men who underwent mpMRI, 93 (47.7%) men had a total of 109 APLs. Prior negative SBx was associated with the presence of APLs in AA men (Odds ratio = 1.81; 9...Continue Reading

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Citations

May 4, 2016·Abdominal Radiology·Arvin K GeorgePeter A Pinto
Jun 17, 2016·International Urology and Nephrology·Akhil MuthigiPeter A Pinto
Jan 16, 2018·Current Opinion in Urology·Stephanie D PurnellPeter A Pinto
Jan 5, 2020·Prostate Cancer and Prostatic Diseases·Sara M FalzaranoCristina Magi-Galluzzi
Aug 8, 2020·Abdominal Radiology·Cyrus Washington, Curtiland Deville
Nov 4, 2020·The Prostate·Kosj YamoahTimothy R Rebbeck

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