PMID: 6982590Jul 1, 1982Paper

The significance of antinuclear antibodies in juvenile rheumatoid arthritis associated with chronic bilateral iridocyclitis

Acta paediatrica Scandinavica
E M EgeskjoldT Sørensen

Abstract

Serum samples from 8 children with juvenile rheumatoid arthritis (JRA) and chronic bilateral iridocyclitis were significantly distinguished from 5 children with JRA and no eye symptoms by the presence of large immune complexes (IC) greater than 22S, IgM antinuclear antibodies (ANA), IgG granulocyte-specific (GS-) ANA, C3 fixing ANA, and IgM anti-IgG. One serum with and two sera without IC greater than 22S, all from patients with iridocyclitis, were fractionated by rate zonal ultracentrifugation. Each fraction relevant for the study was separately concentrated and reexamined. In one of the sera without IC greater than 22S this technique exposed the presence of IgA GS-ANA not detectable in the corresponding whole serum. IgG ANA were precipitated in an area with higher molecular weight than the one for IgG indicating the presence of aggregated IgG ANA. Fractionation of the serum with IC greater than 22S demonstrated IgM GS-ANA not present in whole serum. The results support previous suggestions that ANA may be involved in the pathogenesis of chronic iridocyclitis and may explain why ANA (in particular C3 fixing ANA) negative patients with JRA rarely develop chronic iridocyclitis.

References

Sep 1, 1979·Fertility and Sterility·N J Alexander, D J Anderson
Jan 1, 1977·The British Journal of Ophthalmology·S OhnoG R O'Connor
Nov 1, 1977·Arthritis and Rheumatism·R D RossenM D Lidsky
Mar 1, 1978·Acta paediatrica Scandinavica·H PerminJ V Knudsen
Aug 1, 1979·Molecular Immunology·C Jacobsen, J Steensgaard
Jun 11, 1975·American Journal of Ophthalmology·L T ChylackJ S Stillman
Jan 1, 1974·Annals of the Rheumatic Diseases·K M Goel, R A Shanks
Sep 1, 1970·European Journal of Biochemistry·J Steensgaard
Sep 1, 1981·Acta paediatrica Scandinavica·E M EgeskjoldH Graudal

❮ Previous
Next ❯

Citations

May 1, 1989·Indian Journal of Pediatrics·E M Egeskjold
Sep 23, 2003·Survey of Ophthalmology·Kaisu KotaniemiKimmo Aho
Feb 1, 1986·Archives of Disease in Childhood·A M LeakS J Burman
Mar 1, 1988·Annals of the Rheumatic Diseases·A M Leak
Jan 1, 1987·Scandinavian Journal of Rheumatology. Supplement·A Martini
May 9, 2012·Pediatric Clinics of North America·Jay Mehta
Feb 1, 1987·Seminars in Arthritis and Rheumatism·A M Rosenberg
Sep 1, 1991·Annals of the Rheumatic Diseases·A M Leak, P Woo
Aug 2, 2002·Pediatric Annals·James N Jarvis
Nov 8, 2001·International Ophthalmology Clinics·N K WaheedC S Foster
Oct 1, 1994·Annals of the Rheumatic Diseases·E SorianoN J McHugh
Apr 1, 1985·Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. Section C, Immunology·E M EgeskjoldM Høier-Madsen
Jul 1, 1985·Scottish Medical Journal·P GaleaK M Goel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved