The significance of cancer cell expression of the chemokine receptor CXCR4

Seminars in Cancer Biology
Fran Balkwill

Abstract

Malignant cells from at least 23 different types of cancer express the chemokine receptor CXCR4 and respond to its ligand CXCL12. This receptor ligand pair appears to be involved in directed migration of cancer cells to sites of metastasis, increased survival of cancer cells in sub optimal conditions and establishment of a tumour promoting cytokine/chemokine network. Preliminary data from animal models suggest that CXCR4 may be an important therapeutic target in a range of cancers. However CXCR4 plays major roles in embryogenesis, homeostasis and inflammation. This raises questions concerning the specificity of CXCR4 antagonists in the treatment of cancer.

References

Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·C C BleulC R Mackay
Jul 27, 1999·Gastroenterology·M B DwinellM F Kagnoff
Oct 19, 1999·The Journal of Clinical Investigation·N J JordanJ Westwick
Apr 20, 2000·Journal of the National Cancer Institute·A CorcioneV Pistoia
Jun 3, 2000·Annual Review of Immunology·D Rossi, A Zlotnik
Sep 5, 2001·Journal of Virology·F BaribaudR W Doms
Sep 26, 2001·The Journal of Biological Chemistry·M M RobledoJ Teixidó
Jun 13, 2002·The Journal of Investigative Dermatology·Aimee S Payne, Lynn A Cornelius
Sep 5, 2002·The Journal of Experimental Medicine·Andrzej PtasznikAlan M Gewirtz
Oct 22, 2002·The Journal of Biological Chemistry·Yan ZhouV Wee Yong
Nov 22, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nicolas B DavidAlain Ghysen
Jan 1, 2003·Nature·Holger KnautUNKNOWN Tübingen 2000 Screen Consortium
Jan 10, 2003·The Journal of Clinical Endocrinology and Metabolism·Jung Hwan HwangMinho Shong
Mar 11, 2003·American Journal of Respiratory and Critical Care Medicine·Roderick J PhillipsRobert M Strieter
Mar 21, 2003·American Journal of Clinical Pathology·Andrew P WengDavid M Dorfman
Apr 10, 2003·Proceedings of the National Academy of Sciences of the United States of America·Toshiaki AraTakashi Nagasawa
May 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Dimitri SemizarovStephen W Fesik
May 23, 2003·Journal of Cellular Biochemistry·Yan-Xi SunRussell S Taichman
Jun 20, 2003·Nature Reviews. Drug Discovery·Erik De Clercq
Jul 5, 2003·Cancer Cell·Yibin KangJoan Massagué

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Citations

Oct 9, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chin-Sheng HungYu-Jia Chang
Aug 29, 2012·Journal of Oncology·Valerie ChewJean-Pierre Abastado
Nov 11, 2008·Journal of Endocrinological Investigation·S GelminiE Lazzeri
May 9, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yanan SunFeng Jin
Jan 7, 2009·Journal of Cancer Research and Clinical Oncology·Juliana Laino do Val CarneiroMaria Angelica Ehara Watanabe
Sep 10, 2008·PPAR Research·Cynthia Lee Richard, Jonathan Blay
Mar 25, 2009·Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society·Frank M SpeetjensPeter J K Kuppen
Jun 29, 2014·Histochemistry and Cell Biology·Maryna MasyukBeate Brand-Saberi
Dec 24, 2013·Future Medicinal Chemistry·Simon P Fricker, Markus Metz
Nov 30, 2010·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·E VoulgarisN Pavlidis
Dec 9, 2014·International Journal of Endocrinology·Federica BarbieriTullio Florio
Dec 3, 2014·Oral Oncology·Joseph RohSufi M Thomas
Mar 29, 2006·The Journal of Experimental Medicine·Dingzhi WangRaymond N DuBois
May 2, 2008·The Journal of Biological Chemistry·Aasia O Rehman, Cun-Yu Wang
Apr 3, 2009·PloS One·Katia BeiderAmnon Peled
Apr 9, 2009·Molecular Therapy : the Journal of the American Society of Gene Therapy·Yongjun LiuChen Lin
Jan 8, 2010·Journal of Cell Science·Amanda P StruckhoffRebecca A Worthylake
Feb 18, 2010·The Journal of Biological Chemistry·Maria I SierraPiers D Nash
Jul 30, 2010·Critical Reviews in Immunology·Gustavo Pacheco-Rodriguez, Joel Moss
Sep 15, 2010·Cancer Metastasis Reviews·Xueqing SunJianhua Wang
Oct 20, 2010·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Orit JacobsonXiaoyuan Chen
Feb 15, 2011·Breast Cancer Research and Treatment·Allison M MichalJeffrey L Benovic
Mar 26, 2011·The Journal of Clinical Investigation·Laura G Schuettpelz, Daniel C Link
May 31, 2011·Frontiers in Bioscience (Scholar Edition)·Rajesh SinghShailesh Singh
May 31, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Ravindra A De SilvaSridhar Nimmagadda
Jun 3, 2011·World Journal of Gastroenterology : WJG·Bao-Cheng ZhaoHui-Min Xu
Sep 29, 2011·PloS One·Jason A WojcechowskyjRobert W Doms

❮ Previous
Next ❯

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