The Significance of Circulating Tumour Cells in the Clinic

Acta Cytologica
Sara Abalde-CelaLorena Diéguez

Abstract

Despite the hype about circulating tumour cells (CTCs) in the early 2000s and their potential in the diagnosis of metastasis, in recent years, the hope for personalised cancer management relies more on circulating tumour (ct)DNA that has entered the clinic in a much more efficient way. So far, approved methods for CTCs in the clinic only provide the counting of CTCs, which enables monitoring of the progression of metastatic breast, prostate, and colorectal cancer patients with therapy. Approved methods for ctDNA facilitate the analysis of specific mutations in lung cancer, thereby providing indications for potentially successful treatments. This situation inclined the balance towards molecular analysis in liquid biopsy, leveraged by new technologies and companies providing broader mutation and gene expression analysis towards the early diagnosis of cancer. We conducted a search for the studies published to date that provide details about the significance of CTCs in the clinic. Many studies and clinical trials have demonstrated the potential of CTCs in patient screening, early diagnosis, therapy resistance, and patient prognosis. Large multi-centre studies are still needed to formally validate the clinical relevance of CTCs. Met...Continue Reading

References

Aug 20, 2004·The New England Journal of Medicine·Massimo CristofanilliDaniel F Hayes
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·W Jeffrey AllardLeon W M M Terstappen
Mar 1, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Massimo CristofanilliLeon W M M Terstappen
Oct 21, 2005·The New England Journal of Medicine·Martine J Piccart-GebhartUNKNOWN Herceptin Adjuvant (HERA) Trial Study Team
Jul 22, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Daniel F HayesLeon W W M Terstappen
Nov 7, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·G Thomas BuddDaniel F Hayes
Feb 10, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine RiethdorfKlaus Pantel
Feb 23, 2007·Cancer Letters·Patrizia Paterlini-Brechot, Naoual Linda Benali
Aug 8, 2007·Journal of Cellular Physiology·Honor HugoErik W Thompson
Oct 24, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Michail IgnatiadisDimitris Mavroudis
Jul 2, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Steven J CohenNeal J Meropol
Jul 4, 2008·The New England Journal of Medicine·Shyamala MaheswaranDaniel A Haber
Sep 2, 2008·Nature Cell Biology·Robert A Weinberg
Sep 4, 2008·Annals of Surgical Oncology·Kunihiko HiraiwaYuko Kitagawa
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Johann S de BonoDerek Raghavan
Mar 14, 2009·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S J CohenN J Meropol
Apr 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nikolaos XenidisDimitris Mavroudis
Apr 4, 2009·The American Journal of Pathology·Michael W Klymkowsky, Pierre Savagner
May 6, 2009·Stem Cells·Shigeo TakaishiTimothy C Wang
Jun 3, 2009·The Journal of Clinical Investigation·Michael Zeisberg, Eric G Neilson
Apr 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine RiethdorfKlaus Pantel
Feb 9, 2011·The Journal of Cell Biology·Min YuDaniel A Haber
Mar 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Matthew G KrebsFiona H Blackhall
Mar 26, 2011·Science·Christine L Chaffer, Robert A Weinberg
Jun 18, 2011·Journal of Cancer Research and Clinical Oncology·Yun-Fan SunYang Xu
Jun 4, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jeffrey B SmerageDaniel F Hayes
Jun 26, 2014·BioMed Research International·Man LiDan Luo
Aug 16, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Min ChengGui-Feng Liu
Aug 21, 2014·Cancer Discovery·James P SullivanDaniel A Haber
Oct 19, 2014·Journal of Cancer Research and Clinical Oncology·Dandan YuanFeng Bi
Dec 30, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-Yves PiergaPatrice Viens

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Citations

Dec 1, 2019·Current Treatment Options in Oncology·Yimin PanQing Liu
Jul 3, 2019·Acta Cytologica·José Luís Costa, Fernando C Schmitt

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