The significance of classifying microvascular invasion in patients with hepatocellular carcinoma

Annals of Surgical Oncology
Shuji SumieMichio Sata

Abstract

Microvascular invasion (MVI) has been recognized as a risk factor for outcome following curative resection in hepatocellular carcinoma (HCC). Because MVI can range from few to many invaded vessels, we evaluated the significance of MVI classification in this study. Between January 1995 and December 2010, 207 consecutive patients who underwent curative resection for HCC within Milan criteria were included in this retrospective study. Patients were classified into mild and severe MVI groups based on the number of vessels invaded. This study evaluated whether MVI classification can help to predict recurrence and survival after curative resection. Of the total 207 patients, 103 (50 %) patients had no detectable MVI, whereas 59 (28 %) had mild MVI, and 45 (22 %) had severe MVI. Recurrence-free survival rates at 2 years for patients without MVI, with mild MVI, and severe MVI were 75.9, 47.2, and 32.7 %, respectively. Patients with severe MVI experienced a high frequency of fatal recurrence, such as multiple tumors, macroscopic vascular invasion, and extrahepatic metastasis after curative resection. Multivariate analysis revealed age, number of tumors, mild MVI, and severe MVI as independent predictors of recurrence-free survival. Dise...Continue Reading

References

May 30, 2014·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Po-Hong LiuTeh-Ia Huo
Nov 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bin JinGuangdong Pan
Apr 8, 2015·The British Journal of Surgery·S MarubashiM Sakon
Apr 3, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chuan ChenGe Wang
Jul 6, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S M SchlichtemeierT J Hugh
Apr 4, 2016·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Soo Jeong NamJoong-Won Park
Aug 18, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Han WangWen-Ming Cong
Feb 23, 2019·Annals of Surgical Oncology·Derek J Erstad, Kenneth K Tanabe
Apr 19, 2019·Journal of Cellular Physiology·Bing HanLianfeng Zhang
Feb 26, 2016·Oncotarget·Xianteng WangYongyu Shi
Dec 4, 2014·Molecular and Clinical Oncology·Chen-Hsi HsiehShih-Kai Hung
Nov 30, 2016·World Journal of Gastroenterology : WJG·Wen-Ming CongGuideline Committee
Nov 8, 2018·Contrast Media & Molecular Imaging·Vincenzo CuccurulloGiuseppe Lucio Cascini
Sep 19, 2019·World Journal of Clinical Cases·Ling LiuLing Lin
Jun 5, 2020·Journal of Digital Imaging·Giacomo NebbiaShandong Wu
Jun 8, 2018·European Surgery : ACA : Acta Chirurgica Austriaca·Eva BraunwarthFlorian Primavesi
Jun 16, 2018·World Journal of Gastroenterology : WJG·Han-Yu JiangBin Song
Oct 28, 2019·Radiologia brasileira·Daniel Lahan-MartinsElaine Cristina de Ataide
Jun 26, 2020·Cancer Management and Research·Tao ZhangXiuwen Chen

Citations

Nov 1, 1991·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K ShirabeK Sugimachi
Oct 31, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·T TakayamaS Yamasaki
May 9, 2001·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S JonasPeter Neuhaus
Feb 6, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Timothy M PawlikJean-Nicolas Vauthey
Mar 17, 2004·World Journal of Surgery·Ming ShiJin-Qing Li
Mar 26, 2004·Journal of Cancer Research and Clinical Oncology·Bo-Heng ZhangZhao-You Tang
Aug 10, 2005·The American Journal of Gastroenterology·Hidenori ToyodaJunji Washizu
Jul 10, 2007·Journal of the American College of Surgeons·Hauke LangChristoph E Broelsch
Jul 25, 2008·The New England Journal of Medicine·Josep M LlovetSHARP Investigators Study Group
Mar 5, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jordi BruixAmerican Association for the Study of Liver Diseases
Apr 27, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Prashant BhanguiDaniel Azoulay

Related Concepts

Neoplasm Recurrence, Local
TNM Staging System
Glomuvenous Malformations
Blood Vessel
Cirrhosis
Liver Carcinoma
Neoplasms
Recurrent Malignant Neoplasm
Hepatocellular Carcinoma of the Mouse
Recurrence (Disease Attribute)

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Related Papers

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Fumitoshi HirokawaKazuhisa Uchiyama
Liver International : Official Journal of the International Association for the Study of the Liver
K ShirabeYoshihiko Maehara
European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
W-C ZhaoG-S Yang
© 2020 Meta ULC. All rights reserved