PMID: 16505597Mar 1, 2006Paper

The significance of disease-independence in Mikulicz's disease--revival interests in Mikulicz's disease

Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology
Motohisa YamamotoKohzoh Imai

Abstract

Mikulicz's disease represents a unique condition involving enlargement of the lacrimal and salivary glands. Mikulicz's disease has been considered part of primary Sjögren's syndrome because both diseases were histologically similar. However, the gland swellings in Mikulicz's disease are persistent, and its decreased secretional function is good responsiveness to glucocorticoid. Serologically, Mikulicz's disease is characterized by few autoantibody including anti-SS-A and anti-SS-B antibodies. Recently, it is revealed elevated IgG4 concentrations in the serum and prominent infiltration by plasmacytes expressing IgG4 in the lacrimal and salivary glands in Mikulicz's disease. Prominent IgG4-positive plasma cells are also detected in systemic lymph tissues. We cannot detect the phenomenon in Sjögren's syndrome. In complications with Mikulicz's disease, there are autoimmune pancreatitis, retroperitoneal fibrosis, tubulointerstitial nephritis, autoimmune hypophysitis, Riedel's thyroiditis, which are related to IgG4 in its pathogenesis. Mikulicz's disease is different from Sjögren's syndrome, and may be a systemic IgG4-related plasmacytic disease.

References

Jun 1, 1997·British Journal of Rheumatology·T SumidaK Nishioka
Mar 10, 2001·The New England Journal of Medicine·H HamanoK Kiyosawa
Aug 30, 2001·Nature Immunology·C C Whitacre
Mar 19, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Toshiro FukuiTsutomu Chiba
Mar 30, 2005·Scandinavian Journal of Rheumatology·M YamamotoK Imai
Aug 18, 2005·Rheumatology·M YamamotoK Imai
Nov 9, 2005·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Motohisa YamamotoKohzoh Imai

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Citations

Dec 14, 2006·Modern Rheumatology·Motohisa YamamotoKohzoh Imai
Mar 4, 2008·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Motohisa YamamotoYasuhisa Shinomura
Nov 11, 2010·Nihon Jibiinkoka Gakkai kaiho·Hiroto NakadaYasuhiro Kase
Apr 27, 2011·Japanese Journal of Radiology·Tomoharu WatanabeMasumi Kadoya
Jun 12, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Richard D Swartz
Aug 20, 2019·Modern Rheumatology·Hiroto TsuboiTakayuki Sumida
Apr 11, 2012·Current Opinion in Nephrology and Hypertension·Lynn D Cornell
Jan 1, 2011·Case Reports in Immunology·Masayuki IshidaYukio Watanabe

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