PMID: 3757915Apr 1, 1986Paper

The significance of duration of salt loading on cardiovascular response and urinary excretion of catecholamine in rats

Endocrinologia Japonica
M YoshimuraH Ijichi

Abstract

To analyze the conflicting data on the relationship between sodium intake and catecholamine release, the effect of the duration of high sodium loading on cardiovascular response and catecholamine release was examined in conscious rats. Urinary excretions of norepinephrine (NE), and dopamine (DA) were measured frequently over a 4 week period. Male Wistar rats at 4 weeks of age were given a diet containing either basal (0.3%) or high (3.1%) sodium content. Systolic blood pressure was measured weekly by the tail cuff method. Twenty-four hour urine collections were made for analysis of catecholamines in metabolic cages every other day during the initial 2 weeks and once a week in the following 2 weeks of salt loading. High sodium intake resulted in a rise in blood pressure and a reduction in heart rate. Bradycardia was significant during the initial 2 weeks and not significant during the following 2 weeks after the initiation of salt loading. Urinary excretion of NE did not change during the initial 2 weeks of salt loading but increased significantly following the 2 week period after salt loading. Urinary excretion of DA increased diphasically, showing the first peak at 1 week after salt loading and the second peak at 4 weeks after...Continue Reading

Citations

Jan 1, 1992·European Journal of Clinical Pharmacology·F R IbarraE Arrizurieta
Dec 5, 1998·Pharmacology & Therapeutics·P A JoseR A Felder
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·M YoshimuraH Ijichi
Jan 1, 1991·Clinical and Experimental Hypertension. Part A, Theory and Practice·A L JadhavM F Lokhandwala
Sep 13, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Feng-Jie LaiShyi-Jang Shin
May 16, 2015·Journal of the American Society of Nephrology : JASN·Aruna R NatarajanPedro A Jose
Apr 8, 1998·The American Journal of Physiology·M NishimuraM Yoshimura

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