The significance of Epstein-Barr virus seropositivity in multiple sclerosis patients?

Acta Neurologica Scandinavica
M MunchS Haahr

Abstract

The objective of this study was to evaluate and investigate the significance of the previously found 100% seropositivity toward Epstein-Barr virus (EBV) found in multiple sclerosis (MS) patients in contrast to healthy controls. Using a commercially available ELISA-test (Biotest), which differentiates infections with EBV into previous infections, primary infections, reactivated infections and no previous infection, we found 137 of 138 MS patients and 124 of 138 healthy controls seropositive. A primary infection in 4 of the 124 EBV seropositive healthy controls in contrast to no primary infections in the MS EBV seropositive group was significant (P=0.049652, Fishers exact test). This may be suggestive of a lack of primary infections in MS patients, and thus strengthens the idea that MS patients are infected with EBV before development of MS. Further studies are in progress to analyse whether EBV infection is a prerequisite for the development of this disease.

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Citations

Jan 6, 1999·Acta Neurologica Scandinavica·M MunchS Haahr
Mar 21, 2002·Acta Neurologica Scandinavica·R Alvarez-LafuenteR Arroyo
Apr 19, 2007·Multiple Sclerosis : Clinical and Laboratory Research·T R NielsenH Hjalgrim
Mar 16, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sandra Behren, Ulrika Westerlind
Oct 29, 2005·Journal of Neurology·Hans-Peter HartungBernhard Hemmer
Feb 17, 2010·Nature Reviews. Neurology·Adam E HandelSreeram V Ramagopalan
Apr 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·J W LindseyT Vu
Aug 24, 2006·Reviews in Medical Virology·Sven Haahr, Per Höllsberg
May 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G IngramN P Robertson
Mar 2, 2013·Expert Review of Neurotherapeutics·Julia PakpoorSreeram V Ramagopalan
Oct 6, 2000·Epidemiology·A Ascherio, M Munch
Apr 30, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·O SantiagoO Fernandez
Apr 21, 2010·Indian Journal of Medical Microbiology·R KannangaiG Sridharan
Dec 19, 2018·Molecular Immunology·Elie DeebaChristina Christodoulou

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