The significance of extended lymphadenectomy for colorectal cancer with isolated synchronous extraregional lymph node metastasis

Asian Journal of Surgery
Atsushi OguraMasashi Ueno

Abstract

The significance of extended lymphadenectomy for colorectal cancer with extraregional lymph node metastasis, such as para-aortic lymph node metastasis, has not been established. The purpose of this study was to evaluate the significance of extended lymphadenectomy for colorectal cancer with synchronous isolated extraregional lymph node metastasis. Between July 2004 and December 2013, 16 patients with synchronous extraregional lymph node metastasis without other organ metastases underwent curative resection and extended lymphadenectomy (R0 group). The clinical characteristics and survival outcomes of the R0 group were compared with those of 12 patients with extraregional lymph node metastasis who underwent palliative surgery (control group). In the R0 group, the 5-year cancer-specific survival (CSS) rate was 70.3% and the 5-year relapse-free survival (RFS) rate was 60.5%. The 5-year CSS differed significantly between the R0 and control groups (70.3% vs. 12.5%; p = 0.0003). Univariate analyses revealed that the total numbers of metastatic lymph nodes and metastatic regional lymph nodes present were significantly associated with RFS (p = 0.019 for both). Findings from our study suggest that extended lymphadenectomy for colorectal ...Continue Reading

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Citations

Jul 15, 2017·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Sung Uk BaeNam Kyu Kim
May 28, 2021·International Journal of Colorectal Disease·Yoshitoshi IchikawaHidetoshi Eguchi
Jul 1, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Sung Chul LeeJung Kyong Shin

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