Jul 31, 2013

The significance of ferritin in cancer: anti-oxidation, inflammation and tumorigenesis

Biochimica Et Biophysica Acta
Ahmed A Alkhateeb, James Connor

Abstract

The iron storage protein ferritin has been continuously studied for over 70years and its function as the primary iron storage protein in cells is well established. Although the intracellular functions of ferritin are for the most part well-characterized, the significance of serum (extracellular) ferritin in human biology is poorly understood. Recently, several lines of evidence have demonstrated that ferritin is a multi-functional protein with possible roles in proliferation, angiogenesis, immunosuppression, and iron delivery. In the context of cancer, ferritin is detected at higher levels in the sera of many cancer patients, and the higher levels correlate with aggressive disease and poor clinical outcome. Furthermore, ferritin is highly expressed in tumor-associated macrophages which have been recently recognized as having critical roles in tumor progression and therapy resistance. These characteristics suggest ferritin could be an attractive target for cancer therapy because its down-regulation could disrupt the supportive tumor microenvironment, kill cancer cells, and increase sensitivity to chemotherapy. In this review, we provide an overview of the current knowledge on the function and regulation of ferritin. Moreover, we...Continue Reading

  • References177
  • Citations48

References

  • References177
  • Citations48

Citations

Mentioned in this Paper

Establishment and Maintenance of Localization
ErbB-2 Receptor
Biochemical Pathway
Thyrotropin Class in ATC
Insulin-Like Growth Factor I
Brain Diseases
Antineoplastic Agents
Dermatofibrosarcoma Protuberans
T-Lymphocyte
Decreased Immunologic Activity [PE]

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