PMID: 7543432Aug 1, 1995Paper

The significance of immunoglobulin M antibody response to hepatitis C virus core protein in patients with chronic hepatitis C

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
N YukiT Kamada

Abstract

The significance of immunoglobulin (Ig) M antibody to hepatitis C virus core protein (IgM anti-HCV core) was studied in 41 patients with chronic hepatitis C virus (HCV) infection diagnosed by the polymerase chain reaction (PCR). IgM anti-HCVcore was tested with a solid-phase enzyme-linked immunoassay. The results were correlated with clinical features, liver histology findings evaluated by the histological activity index, and virological features such as genotypes and viremic levels assessed by a branched DNA assay. IgM anti-HCVcore was found in 29 (71%) patients, and its occurrence was only related to viremic levels. A significant relationship was observed between viremic levels and IgM anti-HCVcore cut-off index (rs = .42, P < .01). Of the eight low viremic (branched DNA-negative) patients, only two (25%) tested positive for IgM anti-HCVcore with a low cut-off index of < 3, whereas 27 (82%) of the 33 highly viremic (branched DNA-positive) patients had IgM anti-HCVcore (P < .01). After a 28-week interferon-alpha course (IFN-alpha), sustained aminotransferase normalization after therapy withdrawal was achieved by only two (13%) of the 16 patients with IgM anti-HCVcore cut-off index > 3 compared with 11 (44%) of the 25 patients ...Continue Reading

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Citations

May 13, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Henry E Neuman de Vegvar, William H Robinson
Jul 1, 1997·Journal of Hepatology·G V PapatheodoridisN C Tassopoulos
Mar 26, 1999·Diagnostic Microbiology and Infectious Disease·P ToniuttoM Pirisi
Nov 15, 2002·Journal of Viral Hepatitis·L I NikolaevaA I Archakov
Dec 6, 2008·World Journal of Gastroenterology : WJG·Yalena Amador-CañizaresSantiago Dueñas-Carrera
Dec 7, 2013·World Journal of Gastroenterology : WJG·Mohammad IrshadKhushboo Irshad
Jun 9, 2015·World Journal of Hepatology·Hui-Chun Li, Shih-Yen Lo

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