PMID: 2106549Jan 1, 1990Paper

The significance of infections with two types of viral hepatitis demonstrated by histologic features in chimpanzees

Journal of Hepatology
H P DienesA Ponzetto

Abstract

In view of the recognized importance of necroinflammatory episodes in chronic hepatitis B virus (HBV) infection, chimpanzees, either HBV surface antigen (HBsAg) carriers or noninfected (naive), were infected with other primary hepatotropic viruses to evaluate histologic alterations and changes in virologic and biochemical markers of infection. The advantages of studies on chimpanzees are the availability of serial biopsy specimens and the viral type-specific histologic lesions, not as well recognized in humans. Infection with hepatitis A and non-A, non-B (NANB) agents produced more severe lesions in chronic HBsAg carrier chimpanzees than in naive animals. During this superinfection, the specific expression of the second agent was predominant, indicating that the exacerbation is caused by the second agent, but that carriers are prone to more severe disease than the naive chimpanzees. Hepatitis delta virus (HDV) infections were always coexistant with HBV and superinfection of carriers produced histologic changes more severe than those seen in any other type of viral hepatitis. Such HDV infections revealed less evidence of lymphocytotoxicity but rather of cytotoxicity, and sometimes resembled in appearance the histopathology of NA...Continue Reading

References

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Citations

May 1, 1993·Gastroenterologia Japonica·W L ChuangC J Chen
Jan 7, 2010·Nature Reviews. Gastroenterology & Hepatology·Heiner Wedemeyer, Michael P Manns
Apr 1, 1993·Histopathology·R ColombariP J Scheuer
Mar 8, 2000·Microbiology and Molecular Biology Reviews : MMBR·C Seeger, W S Mason
Jun 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Tatsuya AnzaiHidetoshi Inoko
Feb 17, 2015·Pathogens·Rafael AldabeGloria González-Aseguinolaza
Feb 4, 2009·Best Practice & Research. Clinical Gastroenterology·Karsten WursthornHeiner Wedemeyer
Jan 19, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Heiner Wedemeyer
Jan 2, 2003·Nature Reviews. Genetics·Maynard V Olson, Ajit Varki
Mar 11, 2000·British Journal of Nursing : BJN·C Metcalf
May 15, 1998·Acta Paediatrica Japonica; Overseas Edition·Y TazawaT Konno
May 1, 2021·Viruses·Eirini D TseligkaFrancesco Negro

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