PMID: 7517659Jul 1, 1994Paper

The significance of lymphoid follicles in the interpretation of gastric biopsy specimens

Archives of Pathology & Laboratory Medicine
R M Genta, H W Hamner

Abstract

Lymphoid follicles are a common feature of Helicobacter pylori-associated gastritis. Recently, by using gastric mapping, we demonstrated lymphoid follicles in all of 62 patients with H pylori infection. This study was designed to address (1) the prevalence of lymphoid follicles in routine gastric biopsy specimens, (2) their correlation with chronic active gastritis, and (3) their predictive value with respect to H pylori infection. Slides from 174 patients whose gastric biopsy findings carried a nonneoplastic diagnosis were evaluated for the presence of (1) chronic active gastritis, (2) lymphoid follicles, and (3) H pylori. When either follicles or active gastritis was found, but H pylori could not be identified by the hematoxylin-eosin stain, additional slides were prepared with a newly developed silver-hematoxylin-eosin-alcian blue stain. Active gastritis was present in 153 patients (88%). Helicobacter pylori was identified on hematoxylin-eosin-stained slides in 123 patients and by the modified Steiner stain in 11 additional patients. Thus, 87% of the patients with chronic active gastritis had histologically detectable H pylori infection. One or more lymphoid aggregates were present in 110 patients (82% of patients with H pyl...Continue Reading

Related Concepts

Related Feeds

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.