The significance of microsatellite instability in colorectal cancer after controlling for clinicopathological factors

Medicine
Sanghee KangByung Wook Min

Abstract

The colorectal cancer (CRC) patients with microsatellite instability (MSI) have distinct clinicopathological characteristics consisting of factors predicting positive and negative outcomes, such as a high lymph node harvest and poor differentiation. In this study, we measured the value of MSI as a prognostic factor after controlling for these discrepant factors. A total of 603 patients who underwent curative surgery for stages I to III colorectal cancer were enrolled. The patients were divided into microsatellite instability high (MSI-H) and microsatellite stable/microsatellite instability low (MSS/MSI-L) groups. Propensity score matching was used to match clinicopathological factors between the 2 groups. MSI-H patients had a high lymph node harvest (median: 31.0 vs 23.0, P < .001), earlier-stage tumors (P < .001), advanced T stage (89.3% vs 74.0%, P = .018), and poor differentiation (19.6% vs 2.0%, P < .001). Survival analysis showed better survival in the MSI-H group, but the difference was not statistically significant (P = .126). Propensity score matching was performed for significant prognostic factors identified by Cox hazard regression. After the matching, the survival difference by MSI status was estimated to be larger ...Continue Reading

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Citations

Apr 28, 2020·Human Molecular Genetics·Maithilee KhotKundan Sengupta
May 6, 2020·World Journal of Clinical Cases·Ioannis KalantzisHarikleia Gakiopoulou
Jun 17, 2020·Therapeutic Advances in Gastroenterology·Gol Golshani, Yue Zhang
Jul 25, 2019·Cancers·Fatima Domenica Elisa De PalmaFrancesco Salvatore
Jul 1, 2020·Cells·Klara CervenaVeronika Vymetalkova
Jan 13, 2021·International Journal of Molecular Sciences·Andrea Katharina LindnerRenate Pichler
Sep 6, 2020·Clinical Colorectal Cancer·Belinda L Sun
Nov 14, 2020·Expert Review of Anticancer Therapy·Marc T Roth, Satya Das
Apr 23, 2021·Molecular & Cellular Proteomics : MCP·Zhiao ShiBing Zhang
Nov 25, 2021·Journal of Clinical Laboratory Analysis·Fenqi Du, Yanlong Liu

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Methods Mentioned

BETA
PCR
surgical resection

Software Mentioned

R for
R package
R
MatchIt

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