The significance of Mycobacterium abscessus subspecies abscessus isolation during Mycobacterium avium complex lung disease therapy

Chest
D E GriffithR J Wallace

Abstract

Isolation of Mycobacterium abscessus subspecies abscessus (MAA) is common during Mycobacterium avium complex (MAC) lung disease therapy, but there is limited information about the clinical significance of the MAA isolates. We identified 53 of 180 patients (29%) treated for MAC lung disease who had isolation of MAA during MAC lung disease therapy. Patients were divided into those without (group 1) and those with (group 2) MAA lung disease. There were no significant demographic differences between patients with and without MAA isolation or between groups 1 and 2. Group 1 and 2 patients had similar total sputum cultures obtained (P = .7; 95% CI, -13.4 to 8.6) and length of follow-up (P = .8; 95% CI, -21.5 to 16.1). Group 2 patients had significantly more total positive cultures for MAA (mean±SD, 15.0 ± 11.1 vs 1.2 ± 0.4; P < .0001; 95% CI, -17.7 to -9.9), were significantly more likely to develop new or enlarging cavitary lesions while on MAC therapy (P > .0001), and were significantly more likely to meet all three American Thoracic Society diagnostic criteria for nontuberculous mycobacterial disease (21 of 21 [100%] vs 0 of 32 [0%]; P < .0001) compared with group 1 patients. Group 1 patients were significantly more likely to have...Continue Reading

References

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Citations

Mar 12, 2016·Expert Review of Respiratory Medicine·Young Ae Kang, Won-Jung Koh
Jul 20, 2016·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kenjiro FurutaToru Hashimoto
Dec 25, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Won-Jung KohO Jung Kwon
Dec 22, 2017·BMC Pulmonary Medicine·Jong Sik LeeJae-Joon Yim
Aug 10, 2018·American Journal of Respiratory and Critical Care Medicine·David E Griffith, Timothy R Aksamit
Dec 12, 2018·PloS One·Steven A CowmanMichael R Loebinger
Jul 7, 2020·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Charles L DaleyKevin L Winthrop
Mar 21, 2018·Current Infectious Disease Reports·Elizabeth Ann MischJames Muse Davis
Mar 24, 2017·The Journal of Antimicrobial Chemotherapy·Faiza MougariUNKNOWN French National Reference Center for Mycobacteria
Sep 3, 2020·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·Keiji FujiwaraKozo Morimoto
Oct 21, 2020·Chest·David E Griffith, Timothy R Aksamit
Apr 29, 2021·Journal of Medical Microbiology·Amanda BordinDavid M Whiley

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