The significance of myositis autoantibodies in idiopathic inflammatory myopathy concomitant with interstitial lung disease.

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Hung-Ling HuangYuan-Ting Sun

Abstract

This study identified factors associated with interstitial lung disease (ILD) in patients with idiopathic inflammatory myopathy (IIM) based on the latest classification and recent advances in autoantibody serology. We retrospectively analyzed data of 173 patients who underwent complete myositis autoantibody serology examination in a medical center in Taiwan from July 2018 to February 2020. After exclusion of patients who did not receive a final diagnosis of IIM, clinical features, serology data, concomitant diseases, treatment, presence of respiratory failure, and mortality rate of the remaining 97 patients were analyzed. Of IIM patients in our cohort, 47.4% had ILD. ILD was significantly associated with subtypes of IIM, older age of onset, presence of mechanic's hand, and presence of anti-Jo-1 and anti-Ro52 antibodies. Among five IIM subtypes, overlap myositis (OM) and dermatomyositis (DM) were significantly associated with a higher prevalence rate of ILD (67.5% in OM and 53.3% in DM). Among patients with OM, the presence of anti-Jo-1 (100%), anti-PL-7 (100%), and anti-EJ antibodies (77.8%) was most significantly associated with ILD. The latest classification of IIM, older age of onset, presence of mechanic's hand, and presenc...Continue Reading

References

Apr 18, 2003·Seminars in Arthritis and Rheumatism·Armin SchnabelWolfgang L Gross
Feb 11, 2010·Postgraduate Medical Journal·Manish DugarPeter John Roberts-Thomson
Apr 2, 2011·Current Rheumatology Reports·Elena KatzapGalina Marder
Nov 15, 2011·Seminars in Arthritis and Rheumatism·Isabelle MarieFabienne Jouen
Mar 1, 2012·Current Rheumatology Reports·Tsuneyo MimoriYuji Hosono
May 9, 2012·ISRN Rheumatology·João Pedro FerreiraCarlos Vasconcelos
Jul 28, 2013·Current Rheumatology Reports·Patrick D W Kiely, Felix Chua
Jun 2, 2015·European Respiratory Review : an Official Journal of the European Respiratory Society·Jean-Christophe LegaVincent Cottin
Oct 2, 2015·Clinical Reviews in Allergy & Immunology·Minoru SatohEdward K L Chan
May 4, 2016·Seminars in Arthritis and Rheumatism·Ernesto Trallero-AraguásUNKNOWN IIM Study Group and Autoimmune Diseases Study Group (GEAS) of the Spanish Society of Internal Medicine (SEMI)
May 24, 2016·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Mineto OtaHitoshi Kohsaka
Aug 19, 2016·Current Opinion in Neurology·Olivier BenvenisteYves Allenbach
Apr 7, 2017·Arthritis & Rheumatology·Jean-Luc SenécalYves Troyanov
Mar 20, 2018·Current Rheumatology Reports·Valérie Leclair, Ingrid E Lundberg
Apr 14, 2018·Nature Reviews. Rheumatology·Ingrid E LundbergVictoria P Werth
Apr 21, 2018·Nature Reviews. Rheumatology·Neil J McHugh, Sarah L Tansley
Jun 6, 2018·Journal of Neuromuscular Diseases·Jens Schmidt
Aug 4, 2018·Current Opinion in Rheumatology·Micaela FrediFranco Franceschini
Aug 22, 2018·Lancet Neurology·Albert Selva-O'CallaghanAndrew L Mammen
Jan 8, 2019·Journal of the Neurological Sciences·Liubing LiYongzhe Li
Apr 26, 2019·Annals of the Rheumatic Diseases·Sara SabbaghUNKNOWN Childhood Myositis Heterogeneity Collaborative Study Group
May 29, 2019·Seminars in Respiratory and Critical Care Medicine·Thomas BarbaVincent Cottin
May 30, 2019·Frontiers in Neurology·Bruno StuhlmüllerEugen Feist
Jan 27, 2020·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hung-Ling HuangYuan-Ting Sun
Apr 15, 2020·Best Practice & Research. Clinical Rheumatology·Joanna L Marco, Bridget F Collins

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