The Significance of Scalp Involvement in Pemphigus: A Literature Review

BioMed Research International
Marta Sar-PomianMalgorzata Olszewska

Abstract

Scalp is a unique location for pemphigus because of the abundance of desmogleins localized in hair follicles. Scalp involvement is observed in up to 60% of patients in the course of pemphigus. The lesions may occasionally lead to alopecia. Unforced removal of anagen hairs in a pull test is a sign of high disease activity. Direct immunofluorescence of plucked hair bulbs is considered a reliable diagnostic method in patients with pemphigus. Follicular acantholysis is a characteristic histopathological feature of pemphigus lesions localized on the scalp. Trichoscopy may serve as a supplementary method in the diagnosis of pemphigus. This review summarizes the most recent data concerning scalp involvement in pemphigus vulgaris and pemphigus foliaceus. A systematic literature search was conducted in three medical databases: PubMed, Embase, and Web of Science. The analysis included literature data about desmoglein distribution in hair follicles, as well as information about clinical manifestations, histopathology, immunopathology, and trichoscopy of scalp lesions in pemphigus and their response to treatment.

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Citations

Nov 7, 2019·Dermatologic Therapy·Aayush GuptaAishwarya Patil
Aug 1, 2019·Anais Brasileiros De Dermatologia·Adriana Maria PorroMilvia Maria Simões E Silva Enokihara
Oct 6, 2020·International Journal of Dermatology·Maryam GhiasiMaryam Daneshpazhooh
Dec 23, 2019·Clinics in Dermatology·Sonali NandaMariya Miteva
Jan 1, 2019·Anais Brasileiros De Dermatologia·Adriana Maria PorroSilva Enokihara
Jun 25, 2021·Expert Review of Clinical Immunology·Ali NiliMaryam Daneshpazhooh

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