The significance of subclinical rejection

Clinical Transplantation
Jose-Marie El-Amm, Scott A Gruber

Abstract

Subclinical rejection (SCR) is quite common early following renal transplantation and decreases progressively with time. The immunological profile of the recipient, the immunosuppressive regimen used, and the occurrence of prior episodes of clinical acute rejection (AR) are all risk factors for SCR. SCR, in turn, is a risk factor for chronic interstitial and tubular fibrosis and has been associated with worse glomerular filtration rate (GFR) and graft survival. Early SCR should be initially treated with pulse steroids. SCR is a form of biopsy-proven AR and, particularly if treated, must be fairly reported and displayed as a solid endpoint in clinical studies.

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Citations

Jul 15, 2015·Expert Opinion on Pharmacotherapy·Jamal BamoulidKlemens Budde
Apr 11, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·David BuobMarc Hazzan
Jan 10, 2012·Transplant International : Official Journal of the European Society for Organ Transplantation·Hieu LedinhOlivier Detry

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