PMID: 3766212Jan 1, 1986Paper

The significance of the enterohepatic circulation on the metabolism of digoxin in patients with the ability of intestinal conversion of the drug

Acta Medica Scandinavica
K Nørregaard-HansenK E Pedersen

Abstract

A cardiac patient had to be given a very high dosage of digoxin to attain therapeutic plasma level. The increased dosage requirement could partly be explained by reduced bioavailability due to intestinal conversion of digoxin. Consequently, the kinetics of the drug was examined before and after erythromycin treatment. Before treatment the determination of the area under the concentration versus time curve (AUC) following a single dose of digoxin given orally or intravenously demonstrated a substantial reduction in the absolute bioavailability. Erythromycin administration during 20 days caused a dramatic rise in AUC when the single oral dose was repeated, exceeding the two AUC obtained prior to initiation of the antibiotic therapy, and the steady state plasma digoxin level was 2-3-fold increased. The fact that the AUC obtained for a single oral dose of digoxin after erythromycin treatment exceeded that obtained when given intravenously before erythromycin indicated the presence of an enterohepatic circulation of digoxin. This may contribute substantially to the elimination of digoxin in patients with the capability of intestinal conversion of digoxin.

References

Jan 1, 1977·Clinical Pharmacokinetics·E Iisalo
Apr 1, 1976·Clinical Pharmacology and Therapeutics·J H Caldwell, C T Cline
Oct 1, 1981·The New England Journal of Medicine·J LindenbaumJ R Saha
Sep 1, 1981·Clinical Pharmacology and Therapeutics·K E PedersenF Nielsen-Kudsk

❮ Previous
Next ❯

Citations

Sep 1, 1989·DICP : the Annals of Pharmacotherapy·M R Morton, J W Cooper
Sep 20, 1997·The Annals of Pharmacotherapy·P Laberge, P Martineau
Apr 20, 2000·The Annals of Pharmacotherapy·T MiuraY Suzuki
Jul 1, 1997·The Annals of Pharmacotherapy·J J NawarskasS A Spinler
Sep 20, 1997·The Annals of Pharmacotherapy·E D Bizjak, V F Mauro
Jan 1, 1990·Pharmacology & Therapeutics·K F IlettR F Minchin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.