The significance of the initial symptom in Chinese patients with upper tract urothelial carcinoma: Regular health examination is still underutilized

The Kaohsiung Journal of Medical Sciences
Dong FangLiqun Zhou

Abstract

This paper is to elucidate the correlation between different symptoms of UTUC and the clinicopathological characteristics and prognosis. The clinicopathological data of 700 consecutive patients with UTUC who were treated with radical nephroureterectomy were reviewed, and symptoms were categorized into three groups: S1-no direct symptoms, S2-local symptoms (including hematuria and flank pain) and S3-systemic symptoms. We found that the distributions of patients in the S1, S2 and S3 groups were 96 (13.7%), 601 (85.9%) and 3 (0.4%), respectively, and most patients in S1 were incidentally found to have abnormal findings on ultrasound during regular health examination. Altogether, 534 patients (76.3%) presented with gross hematuria, and 111 (15.9%) presented with flank pain. Patients in S1 had a higher rate of hydronephrosis (p < 0.001), ureteral tumors (p < 0.001), worse pre-operative renal function (p = 0.020) and lower tumor stage (p = 0.038). The presence of hematuria was significantly related with renal pelvic tumors (p < 0.001), higher pre-operative eGFR (p = 0.047), papillary tumor architecture (p = 0.005) and less hydronephrosis (p < 0.001); and the presentation of flank pain was correlated with older age (p = 0.008), ureter...Continue Reading

References

Feb 5, 1998·CA: a Cancer Journal for Clinicians·S H LandisP A Wingo
Oct 12, 2000·The Journal of Urology·J J Munoz, L M Ellison
Feb 3, 2006·The New England Journal of Medicine·Patrick W SerruysAndrew T L Ong
Sep 22, 2006·Journal of the American Society of Nephrology : JASN·Ying-Chun MaHai-Yan Wang
Jan 22, 2009·Cancer·Vitaly MargulisUNKNOWN Upper Tract Urothelial Carcinoma CollaborationThe Upper Tract Urothelial Carcinoma Collaboration
Mar 14, 2012·Nature Reviews. Urology·Nigel C Cowan
Dec 10, 2013·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Julien Rhéaume-LanoieAn Tang
Sep 17, 2014·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·P PuechP Colin

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