The significance of the Trp 64 Arg mutation of the beta3-adrenergic receptor gene in impaired glucose tolerance, non-insulin-dependent diabetes mellitus, and insulin resistance in Japanese subjects

Metabolism: Clinical and Experimental
N AzumaK Nakao

Abstract

It has been reported that the Trp 64 Arg mutation of the human beta3-adrenergic receptor (beta3-AR) gene is related to an earlier age of onset of non-insulin-dependent diabetes mellitus (NIDDM) and features of insulin resistance and weight gain in morbidly obese patients. However, such findings have not been consistent in varying ethnic populations. In the present study, we investigated the frequency of the Trp 64 Arg mutation of the human beta3-AR gene in Japanese control subjects (n = 253) and in NIDDM (n = 314) and impaired glucose tolerance (IGT) patients (n = 100). We compared the frequency of the mutation with the body-mass index (BMI) in these groups and with the metabolic clearance rate (MCR) of glucose in the NIDDM patients. A Trp 64 Arg mutation was observed in 36.7%, 31.6%, and 37.0% of the control, NIDDM, and IGT subjects, respectively. The frequency of the homozygotes for the mutation was 4.3%, 4.8%, and 3.0%, respectively. Neither the genotype frequency (Trp/Arg, Arg/Arg) nor the frequency of the mutated allele was significantly different among the three groups. The BMI of the subjects with the mutation was not significantly higher than that of the subjects without the mutation in each group. Furthermore, the alle...Continue Reading

References

Oct 1, 1991·The Journal of Clinical Endocrinology and Metabolism·J F Caro
Sep 8, 1989·Science·L J EmorineA D Strosberg
Nov 1, 1988·Analytical Biochemistry·T A CiullaS L Hauser
Jan 1, 1994·Trends in Pharmacological Sciences·L EmorineA D Strosberg

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Citations

Jun 3, 2005·Current Diabetes Reports·Takahisa Hirose, Ryuzo Kawamori
Jun 4, 2011·Progress in Retinal and Eye Research·Johnny Tang, Timothy S Kern
Feb 19, 1999·Obesity Research·L PérusseC Bouchard
Mar 13, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·W L LoweR S Cooper
May 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K EndoS Tomura
Sep 10, 2013·EMBO Molecular Medicine·Christopher R HeierKanneboyina Nagaraju

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