The significance of vertical mitosis in epidermis

The British Journal of Dermatology
W S Bullough, E Mitrani

Abstract

In normal epidermis mitosis usually occurs in a plane horizontal to the dermo-epidermal junction, both daughter cells then remaining basal while an adjacent non-mitotic cell is detached from the baseline and forced distally. The evidence now indicates that only cells in a certain intermitotic state, called GIb, can be thus detached, and that when such cells are not locally available the expanding mitosis is forced into the vertical axis. The higher the mitotic rate the shorter is the intermitotic interval, and therefore the less probable it becomes that GIb cells will be locally available for extrusion and the more probable that mitosis will take place vertically. At the highest mitotic rates, as in hair bulbs, all mitoses are vertical. The relation of these findings to epidermal structure and to epidermal cellular homeostasis is discussed.

References

Oct 1, 1976·British Journal of Obstetrics and Gynaecology·C H Bullough
Oct 1, 1975·The British Journal of Dermatology·W S Bullough, J U Deol
Jun 3, 1961·Nature·S M CATTANEOF G SHERMAN
Jul 1, 1965·The American Journal of Anatomy·J P MARQUES-PEREIRA, C P LEBLOND
Mar 1, 1991·World Journal of Microbiology & Biotechnology·V B ManilalC Balagopalan

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Citations

Jan 1, 1980·Pharmacology & Therapeutics·E Christophers, E B Laurence
Jan 1, 1981·Bio Systems·E Mitrani
May 1, 1990·Cell and Tissue Kinetics·J Lamprecht
Sep 1, 1978·The British Journal of Dermatology·E Mitrani
Dec 1, 1984·The British Journal of Dermatology·E Mitrani

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