The Significance of VSIG4 Expression in Ovarian Cancer

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Jung Mi ByunKi Tae Kim

Abstract

The protein V-set and Ig domain-containing 4 (VSIG4), a novel B7 family-related macrophage protein with the capacity to inhibit T-cell activation, has a potential role in cancer. Here we suggest its possibility as a therapeutic target and prognostic biomarker of ovarian cancer. Between January 2011 and June 2015, tumor tissues and peripheral blood samples were obtained during surgery from 10 patients with benign ovarian tumors and 22 patients with ovarian cancers. Messenger RNA and protein expression levels of VSIG4 in benign tumor and cancer tissues were examined by the reverse transcription polymerase chain reaction and Western blot, respectively. Soluble VSIG4 concentrations were measured by an enzyme-linked immunosorbent assay. The correlation between VSIG4 expression and the prognosis of ovarian cancer was analyzed according to the patients' clinicopathologic characteristics. VSIG4 messenger RNA and protein expression levels in ovarian cancer tissues were higher than those in benign ovarian tumors (P = 0.0013 and 0.0001, respectively). Soluble VSIG4 concentrations were increased in patients with ovarian cancer compared with that in patients with benign ovarian tumors (P = 0.0452). Moreover, soluble VSIG4 levels were signif...Continue Reading

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Citations

Aug 29, 2020·Aging Cell·Brandon M HallAndrei V Gudkov
Jan 11, 2020·Frontiers in Immunology·Usma MunawaraAntonio Ferrante
Aug 25, 2020·The Journal of Obstetrics and Gynaecology Research·Gyun-Ho JeonDae Hoon Jeong
Jan 29, 2020·FEBS Letters·Szilvia LukácsiAnna Erdei
Sep 19, 2018·Molecular Cancer Research : MCR·Daniella Bianchi-FriasPeter S Nelson
May 26, 2021·Statistics in Medicine·Yi LiSijian Wang

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