The significant effect of HLA-DRB1 matching on acute rejection in kidney transplants

Transplant International : Official Journal of the European Society for Organ Transplantation
M NojimaF Ikoma

Abstract

The object of the present study was to confirm the HLA-DRB1 matching effect on rejection crisis, its severity, and kidney graft survival based on genotyping. Ninety-four renal allografts were included in this study. DNA typing of HLA-DRB1 was performed by the polymerase chain reaction sequence-specific oligonucleotide method. The incidence of acute rejection within 6 months following transplantation, the frequency of OKT3 administration for steroid-resistant rejection, histopathological findings, and graft survival rate were compared between the DRB1-matched (n = 23) and DRB1-mismatched (n = 71) groups. Four acute rejections occurred in the DRB1-matched group (incidence; 17%) and 40 in the DRB1-mismatched group (56%). In the DRB1-matched group, the incidence of acute rejection was significantly less frequent than that of the DRB1-mismatched group (P < 0.005). In the DRB1-matched group, only one patient received OKT3 administration (4%), in contrast to 16 of 71 patients in the DRB1-mismatched group (23%). The use of OKT3 was significantly less frequent in the DRB1-matched group (P < 0.05). Histopathological findings from biopsy specimens showed no constant distribution of pathological grades of acute rejection according to DRB1 ...Continue Reading

References

Aug 1, 1992·Transplantation·T KobayashiH Takagi
Jul 15, 1995·Transplantation·B J NankivellJ R Chapman
May 1, 1993·Transplantation·G P BasadonnaJ S Najarian
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·Y IchikawaS Nagano
Jan 1, 1994·Transplant International : Official Journal of the European Society for Organ Transplantation·S UemotoK Ozawa

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Citations

Jan 3, 2001·The Journal of Clinical Investigation·K C SonntagC LeGuern

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