The significant impact of apigenin on different aspects of autoimmune disease

Inflammopharmacology
Neda KasiriNahid Eskandari

Abstract

Autoimmune diseases are among the highest diseases to diagnose and treat. The current "gold standard" of care for these diseases is immunosuppressive drugs which interfere with overall immune responses; their long-term high-dose treatments would expose the patient to opportunistic, life-threatening and long-term malignant infections. Considering the side effects and toxicity of these drug and also the beneficial effects of herbal compounds among their consumers, the professional investigation on the exact mechanism of the plant's major element has grown much attention in the last years. Apigenin as an extracting compound of plants, such as parsley and celery, which has a variety of biological effects, such as anti-inflammatory, anti-cancer and antioxidant effects. This review is intended to summarize the various effects of Apigenin on several autoimmune diseases which have been worked on so far. The pluralization of the obtained results has revealed Apigenin's effects on pro-inflammatory cytokines such as IL-1β, chemokines such as ICAM-1, immune cells proliferation such as T cells, apoptosis, and various signaling pathways. According to these preclinical findings, we recommend that further robust unbiased studies should be done...Continue Reading

References

Mar 11, 1993·The New England Journal of Medicine·P FroguelP Passa
Dec 26, 2001·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·E B BorthwickA Burchell
Jan 29, 2003·The Journal of Nutritional Biochemistry·Kelly E. HeimDennis J. Bobilya
Mar 12, 2003·Biochemical Pharmacology·Jerome J A HendriksChristine D Dijkstra
Nov 12, 2003·Biochemical Pharmacology·Jim O'PreyPaul R Harrison
Mar 10, 2004·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Jasminka KorcokS Jeffrey Dixon
Mar 5, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jing FangBing-Hua Jiang
Jun 11, 2005·Biochemical Pharmacology·Richard VerbeekJohannes M van Noort
Sep 5, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arnon KarniHoward L Weiner
Jan 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ryan M O'ConnellDavid Baltimore
Jul 10, 2007·The Journal of Clinical Endocrinology and Metabolism·George S Eisenbarth
Sep 27, 2008·Journal of Neuroinflammation·Kavon Rezai-ZadehR Douglas Shytle
Oct 20, 2009·The International Journal of Biochemistry & Cell Biology·Stefan K Drexler, Brian M Foxwell
Nov 26, 2009·Journal of Neuroimmunology·Roopali GandhiHoward L Weiner
Jan 30, 2010·Arthritis and Rheumatism·Heidi KokkonenSolbritt Rantapää Dahlqvist
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Farideh SabehStephen J Weiss
Sep 22, 2010·World Journal of Gastroenterology : WJG·Roja RahimiMohammad Abdollahi
Feb 2, 2011·The Journal of Allergy and Clinical Immunology·Cagri Yildirim-Toruner, Betty Diamond
Mar 8, 2011·Seminars in Immunology·Lars KlareskogLars Alfredsson
Jul 13, 2011·Fitoterapia·Anjali B GanjareAnuja N Patil
Nov 16, 2011·Molecular Cancer Therapeutics·Amit BudhrajaXianglin Shi
Dec 22, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pawel Kalinski
Dec 1, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Christopher D LucasAdriano G Rossi
Oct 30, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Feng ZhangGang Chen
Jan 1, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Arumugam PalanichamyJennifer H Anolik
May 23, 2014·Current Biology : CB·Michael Schieber, Navdeep S Chandel
Feb 11, 2015·Molecular and Cellular Biochemistry·Rajeshwari H PatilS Chidananda Sharma
May 15, 2015·Journal of Global Health·Igor RudanUNKNOWN Global Health Epidemiology Reference Group (GHERG)
Jun 5, 2015·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Rashida GinwalaZafar K Khan
Jul 17, 2015·Deutsches Ärzteblatt International·Annegret KuhnMatthias Schneider

❮ Previous
Next ❯

Citations

Oct 9, 2020·Food & Function·Jing LuShuang Guan
Feb 15, 2020·Current Protein & Peptide Science·Sheetal RamaniSagarika Biswas
Nov 15, 2019·Current Topics in Medicinal Chemistry·Sachin KumarHimangini Bansal
Aug 5, 2021·Current Research in Toxicology·Somesh BanerjeePartha Roy

❮ Previous
Next ❯

Methods Mentioned

BETA
MDA
GTPase
environmental stress
flow cytometry

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.

Related Papers

Anti-cancer Agents in Medicinal Chemistry
Xin Tong, Jill C Pelling
Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Zhao-duan LiangFang He
© 2022 Meta ULC. All rights reserved