The Simbios National Center: Systems Biology in Motion.

Proceedings of the IEEE
Jeanette P SchmidtR B Altman

Abstract

Physics-based simulation is needed to understand the function of biological structures and can be applied across a wide range of scales, from molecules to organisms. Simbios (the National Center for Physics-Based Simulation of Biological Structures, http://www.simbios.stanford.edu/) is one of seven NIH-supported National Centers for Biomedical Computation. This article provides an overview of the mission and achievements of Simbios, and describes its place within systems biology. Understanding the interactions between various parts of a biological system and integrating this information to understand how biological systems function is the goal of systems biology. Many important biological systems comprise complex structural systems whose components interact through the exchange of physical forces, and whose movement and function is dictated by those forces. In particular, systems that are made of multiple identifiable components that move relative to one another in a constrained manner are multibody systems. Simbios' focus is creating methods for their simulation. Simbios is also investigating the biomechanical forces that govern fluid flow through deformable vessels, a central problem in cardiovascular dynamics. In this applic...Continue Reading

References

Jan 1, 1990·Annual Review of Biochemistry·T R Cech
Aug 1, 1990·IEEE Transactions on Bio-medical Engineering·S L DelpJ M Rosen
Jan 1, 1995·Computers in Biology and Medicine·S L Delp, J P Loan
Jan 1, 1993·Journal of Biomechanics·F E Zajac
Oct 3, 2000·Nature·B T WimberlyV Ramakrishnan
Oct 4, 2000·Proceedings of the National Academy of Sciences of the United States of America·A HoudusseC Cohen
Apr 3, 2001·Science·M M YusupovH F Noller
May 18, 2001·Trends in Biotechnology·M Tomita
Sep 25, 2001·Journal of Magnetic Resonance·C D Schwieters, G M Clore
Oct 17, 2001·Journal of Biomechanical Engineering·F C Anderson, M G Pandy
Feb 19, 2002·Chemical Reviews·Christopher J. Cramer, Donald G. Truhlar
Apr 18, 2002·Current Opinion in Structural Biology·Tomas HanssonWilfredF van Gunsteren
Jul 23, 2002·Current Opinion in Chemical Biology·Brian K ShoichetJohn J Irwin
Aug 29, 2002·Nature Structural Biology·Martin Karplus, J Andrew McCammon
Nov 8, 2002·Nature·Christopher D SnowMartin Gruebele
Feb 22, 2003·Journal of Biomechanics·Darryl G ThelenScott L Delp
Mar 30, 2005·Biochemistry·D Thirumalai, Changbong Hyeon
May 28, 2005·Current Opinion in Structural Biology·Brian J Tucker, Ronald R Breaker
Sep 1, 2006·The Journal of Chemical Physics·Pavel A Golubkov, Pengyu Ren
Aug 31, 2007·Science·M Shirts, V S Pande
Nov 21, 2007·IEEE Transactions on Bio-medical Engineering·Scott L DelpDarryl G Thelen
Jun 24, 2008·Computer Methods in Biomechanics and Biomedical Engineering·R Y KwonC R Jacobs

❮ Previous
Next ❯

Citations

Nov 29, 2011·Biomechanics and Modeling in Mechanobiology·Dibyendu SenguptaAlison L Marsden
Jul 12, 2012·Biomechanics and Modeling in Mechanobiology·Shawn C Shadden, Sahar Hendabadi
Dec 10, 2013·Annals of Biomedical Engineering·Jessica M OakesIrene E Vignon-Clementel
Feb 10, 2011·Journal of Biomechanical Engineering·Sethuraman Sankaran, Alison L Marsden
Jul 5, 2012·Journal of Biomechanical Engineering·Mahdi Esmaily MoghadamUNKNOWN Modeling of Congenital Hearts Alliance (MOCHA) Investigators
Feb 1, 2013·Journal of Biomechanical Engineering·Weiguang YangAlison L Marsden
Sep 21, 2013·Physics of Fluids·Mahdi Esmaily-MoghadamAlison L Marsden
Jan 31, 2014·Proceedings. Biological Sciences·Tatsuya AmanoWilliam J Sutherland
Sep 7, 2012·Physics of Fluids·Amirhossein Arzani, Shawn C Shadden
Dec 21, 2010·Nonlinear Dynamics·Ajay SethScott Delp
Feb 5, 2016·Biomechanics and Modeling in Mechanobiology·Weiguang YangIrene E Vignon-Clementel
Apr 6, 2013·International Journal for Numerical Methods in Biomedical Engineering·Vincent DuvernoisShawn C Shadden
May 1, 2012·International Journal for Numerical Methods in Biomedical Engineering·C C LongA L Marsden
Feb 5, 2014·International Journal for Numerical Methods in Biomedical Engineering·Amirhossein ArzaniShawn C Shadden
Jan 25, 2014·International Journal for Numerical Methods in Biomedical Engineering·Jun-Mei ZhangRu San Tan
Apr 24, 2010·Congenital Heart Disease·Alison L MarsdenJeffrey A Feinstein
Jul 23, 2011·IEEE/ACM Transactions on Computational Biology and Bioinformatics·Samuel Coulbourn FloresRuss Biagio Altman
Sep 3, 2013·The Journal of Surgical Research·Gregory ArbiaUNKNOWN Modeling Of Congenital Hearts Alliance (MOCHA) Investigators
Dec 3, 2014·The Journal of Thoracic and Cardiovascular Surgery·Weiguang YangJeffrey A Feinstein
Nov 15, 2011·Journal of the American Medical Informatics Association : JAMIA·Scott L DelpRuss B Altman
Dec 15, 2017·Journal of Biomechanical Engineering·Hongzhi LanAlison L Marsden
May 6, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·R S MacLeodC R Johnson
Jul 23, 2014·Cardiovascular Engineering and Technology·Ethan KungAlison Marsden
Dec 23, 2014·Journal of Biomechanical Engineering·Mahdi Esmaily-MoghadamAlison Marsden
Oct 19, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Amirhossein ArzaniShawn C Shadden
Jun 25, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Ian A CarrShawn C Shadden
Jul 22, 2021·Bioinspiration & Biomimetics·Chunyan RongAndre Rosendo
Jan 1, 2011·Procedia IUTAM·Michael A ShermanScott L Delp

❮ Previous
Next ❯

Related Concepts

Related Feeds

BioHub - Researcher Network

The Chan-Zuckerberg Biohub aims to support the fundamental research and develop the technologies that will enable physicians to cure, prevent, or manage all diseases in our childrens' lifetimes. The CZ Biohub brings together researchers from UC Berkeley, Stanford, and UCSF. Find the latest research from the CZ Biohub researcher network here.