The Simpson grading in meningioma surgery: does the tumor location influence the prognostic value?

Journal of Neuro-oncology
Kira Marie VoßBenjamin Brokinkel

Abstract

In meningiomas, location-specific differences of the prognostic value of the Simpson classification are sparsely investigated but can influence strategy of surgery. We therefore compared the prognostic value of the Simpson classification in different tumor locations. Progression was compared with Simpson grade in 826 meningioma patients (median age 58 years, female:male ratio 2.4) in location-specific uni- and multivariate analyses. Simpson grade strongly correlated with tumor location (p < .001). Within a median follow-up of 50 months, recurrence was observed in 107 of 803 patients (13%). In general, increasing Simpson grade (p = .002) and subtotal resection (STR, ≥grade III) were correlated with tumor recurrence [hazard ratio (HR): 1.87; p = .004]. In 268 convexity meningiomas, frequency of tumor recurrence correlated with Simpson grade (p = .034). Risk of recurrence was similar after grade I and II resections, tended to increase after grade III (HR: 2.35; p = .087) but was higher after grade IV resections (HR: 7.35; p = .003). Risk of recurrence was higher after STR (HR: 4.21; p = .001) than after gross total resection (GTR, ≤grade II). Contrarily, increasing Simpson grade and STR were not correlated with progression in 102 ...Continue Reading

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Citations

Apr 26, 2019·Topics in Magnetic Resonance Imaging : TMRI·Christian D DiehlStephanie E Combs
Sep 29, 2019·Current Treatment Options in Neurology·Michele BailoPietro Mortini
Jun 5, 2019·Neurosurgical Review·Maximilian TimmeBenjamin Brokinkel
Aug 19, 2020·Neurosurgical Review·Benjamin BrokinkelWalter Stummer
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Apr 9, 2018·Neurosurgical Review·Torstein R MelingEirik Helseth
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Jul 7, 2018·Neurosurgical Review·Torstein R MelingEirik Helseth
Jul 22, 2019·Neuroradiology·Yang ZhangMin-Ying Su
Apr 13, 2019·Scientific Reports·Jean-Michel LeméeTorstein R Meling
Nov 16, 2019·Journal of Neuro-oncology·Anne GuyotFrançois Labrousse
Jan 8, 2020·Journal of Clinical Medicine·Yuki KuranariMasahiro Toda
Jul 6, 2018·Acta neurochirurgica·Johanna SickingBenjamin Brokinkel
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Aug 11, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Conor S GillespieMichael D Jenkinson
Nov 19, 2021·Neuro-oncology·Farshad NassiriGelareh Zadeh

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