The Simpson grading revisited: aggressive surgery and its place in modern meningioma management

Journal of Neurosurgery
Konstantinos GousiasMatthias Simon

Abstract

OBJECTIVE Recent advances in radiotherapy and neuroimaging have called into question the traditional role of aggressive resections in patients with meningiomas. In the present study the authors reviewed their institutional experience with a policy based on maximal safe resections for meningiomas, and they analyzed the impact of the degree of resection on functional outcome and progression-free survival (PFS). METHODS The authors retrospectively analyzed 901 consecutive patients with primary meningiomas (716 WHO Grade I, 174 Grade II, and 11 Grade III) who underwent resections at the University Hospital of Bonn between 1996 and 2008. Clinical and treatment parameters as well as tumor characteristics were analyzed using standard statistical methods. RESULTS The median follow-up was 62 months. PFS rates at 5 and 10 years were 92.6% and 86.0%, respectively. Younger age, higher preoperative Karnofsky Performance Scale (KPS) score, and convexity tumor location, but not the degree of resection, were identified as independent predictors of a good functional outcome (defined as KPS Score 90-100). Independent predictors of PFS were degree of resection (Simpson Grade I vs II vs III vs IV), MIB-1 index (< 5% vs 5%-10% vs >10%), histologica...Continue Reading

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Citations

Mar 30, 2016·Acta neurochirurgica·Thomas SantariusRamez W Kirollos
Jul 29, 2016·Acta Neuropathologica·Peter BaumgartenPatrick N Harter
Sep 7, 2016·The Lancet Oncology·Roland GoldbrunnerMichael Weller
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Jan 23, 2020·Journal of Pathology and Translational Medicine·Young Suk Lee, Youn Soo Lee
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Jan 30, 2021·Radiation Oncology·Maximilian I RugeStefan Grau

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