The simultaneous expression of both ephrin B3 receptor and E-cadherin in Barrett`s adenocarcinoma is associated with favorable clinical staging.

European Journal of Medical Research
Matthias C SchauerWolfram Trudo Knoefel

Abstract

In intestinal epithelium, tyrosine kinase receptor Ephrin B3 (Eph B3) maintains the architecture of the crypt-villus axis by repulsive interaction with its ligand ephrin-B1. While loss of Eph B3 is linked to colorectal cancer initiation, overexpression of Eph B3 in cancer cell lines inhibits growth and induces functional changes with decreased mesenchymal and increased epithelial markers. In order to study this tumor suppressor activity of Eph B3 in esophageal adenocarcinoma we analyzed the simultaneous expression of Eph B3 and E-cadherin in both the healthy esophagus and in Barrett's carcinoma. Simultaneous expression of Eph B3 and E-cadherin was investigated in samples from 141 patients with Barrett's carcinoma and from 20 healthy esophagi using immunhistology and quantitative PCR. Results from healthy squamous epithelium, Barrett's metaplasia and staging-specific esophageal adenocarcinoma were correlated. A significantly reduced E-cadherin mRNA expression could be detected in adenocarcinoma compared to dysplasia. The immunhistological activity of E-cadherin and Eph B3 was reduced in adenocarcinoma compared to dysplasia or healthy esophageal mucosa. The intracellular E-cadherin distribution changed significantly from the cyto...Continue Reading

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Citations

Oct 10, 2013·Chinese Journal of Cancer·Rui-Xin LiZhi-Kang Chen
Sep 29, 2015·International Journal of Cancer. Journal International Du Cancer·Britta Liersch-LöhnIdriss M Bennani-Baiti
Jan 16, 2013·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·X-L XuW-M Mao
Aug 28, 2021·International Journal of Molecular Sciences·Alexandros PergarisStamatios Theocharis

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Methods Mentioned

BETA
PCR
surgical resection
biopsy
dissection
biopsies

Software Mentioned

SPSS

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