The Singh Index does not correlate with bone mineral density (BMD) measured with dual energy X-ray absorptiometry (DXA) or peripheral quantitative computed tomography (pQCT)

Archives of Orthopaedic and Trauma Surgery
T O KlatteM Gebauer

Abstract

The Singh Index (SI), a classification system by which the severity of osteoporosis is assessed based on plain radiographs, is a renowned, simple and inexpensive form of evaluating osteoporosis. The aim of this study was to evaluate the correlation between the SI and bone mineral density (BMD) as measured by dual energy X-ray absorptiometry (DXA) and peripheral quantitative computed tomography (pQCT). The SI was evaluated in 128 cadaveric femora (64 patients, mean age 66.7 years, range 24-89 years) by three independent observers, all blinded to plain radiographs. BMD was also analysed by means of DXA and pQCT in the cadaveric femora. The mean interrater correlation was found to be 0.629. The correlation of the mean BMD measured by DXA (DXA-BMD) and SI was found to be poor, with r = 0.49. The corresponding sensitivity of 45.2 % and specificity of 92.3 % were even poor. The BMD measured by pQCT (pQCT-BMD) also revealed a poor correlation with SI, such that r = 0.337 and r = 0.428 for the trochanteric and neck regions, respectively. Due to the poor correlation of the SI with BMD and the poorer interrater correlation, the SI should be rejected as a tool for evaluating osteoporosis. The SI was found to be too imprecise and is theref...Continue Reading

References

Jun 7, 2002·Lancet·Steven R Cummings, L Joseph Melton
Feb 11, 2003·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·D O'GradaighJ E Compston
Aug 6, 2003·Radiologic Clinics of North America·Thomas M Link, Sharmila Majumdar
Sep 29, 2005·The Journal of Clinical Endocrinology and Metabolism·Stephanie BoutroyPierre D Delmas
May 26, 2006·The New England Journal of Medicine·Ego Seeman, Pierre D Delmas
May 16, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Roger M D ZebazeEgo Seeman
Dec 11, 2007·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·J GoldhahnB Hanson
May 3, 2008·European Journal of Radiology·O HauschildP Niemeyer
Apr 3, 2009·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·R D Chapurlat
Jun 28, 2012·JAMA : the Journal of the American Medical Association·Elaine W Yu, Joel S Finkelstein

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