The single nucleotide polymorphism g.1548A >G (K469E) of the ICAM-1 gene is associated with worse prognosis in non-small cell lung cancer.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Eirini ThanopoulouVassilis G Gorgoulis

Abstract

Intercellular adhesion molecule-1 (ICAM-1), a cell adhesion molecule with a key role in inflammation and immunosurveillance, has been implicated in carcinogenesis by facilitating instability of the tumor environment. The K469E single nucleotide polymorphism (SNP) (G>A) affects the ICAM-1 mRNA splicing pattern; the alternatively spliced isoform (ICAM-1-S) lacks transmembrane and intracellular domain, which affects the structural and signal transduction properties. Moreover, the expression of ICAM-1 is transcriptionally regulated by p53, and this SNP has been shown to be related with apoptosis. PCR-RFLP analysis was used to assess the K469E SNP status comparatively in 203 non-small cell lung cancer patients and 175 healthy sex-matched controls. This SNP was examined in relation to tumor kinetic parameters (Ki-67 immunohistochemical evaluation and Tdt-mediated dUTP nick end labeling assay), p53 immunohistochemistry status, and clinicopathological data in patients with operable stages. Both the genotype and allele frequency did not differ significantly between patients and controls. However, patients with the AG/AA genotypes had worse survival (39 vs 45 months, p = 0.036) and tended to be present in advanced stages (p = 0.057). Mor...Continue Reading

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Citations

May 3, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shian-Shiang WangShun-Fa Yang
Mar 25, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaohong FanBo Jin
May 14, 2016·Bulletin of Experimental Biology and Medicine·V V NovikovA V Karaulov
Feb 20, 2020·Biological Reviews of the Cambridge Philosophical Society·Yuanfa YaoYingke Xu
Jul 9, 2014·Molecular Biology Reports·Chao ZhouLiang-An Chen
Dec 3, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Umit YilmazIlhan Yaylim
Nov 17, 2016·Nature Reviews. Molecular Cell Biology·Kassie S Manning, Thomas A Cooper

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