"The sinusoid" in the liver: lessons learned from the original definition by Charles Sedgwick Minot (1900)

The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Kenjiro Wake, Tetsuji Sato

Abstract

The hepatic sinusoid with its associated sinusoidal cells is a multifunctional cell-complex in the liver. Despite recent advances in research on the hepatic sinusoid, no investigator has played a more basic role in its characterization than Charles Sedgwick Minot (1852-1914), a pioneer who distinguished the sinusoid from the blood-capillary as early as 1900. According to Minot, sinusoids are typically larger in diameter than capillaries, particularly at the early embryonic stage. They closely approach the parenchymal tissue, are formed passively by the adjacent parenchymal tissue, and are on rare occasion surrounded with connective tissue. Sinusoids (sinus-like) are small blood-channels formed by subdivision of the lumen of large blood vessels (sinuses) by the invasion of developing parenchymal cell-cords. Although some of Minot's definitions may no longer be accepted, he described some fundamental and interesting characteristics of sinusoids, to which we have not paid much attention. Here, we have attempted to illustrate lessons we have learned from Minot's view point of sinusoids at this occasion of centenary of his death.

References

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Citations

Nov 18, 2017·Archives of Toxicology·Sophia KrauseKai-Uwe Goss
Oct 3, 2019·PeerJ·Thomas N HarveyJacob S Torgersen
Aug 9, 2017·Journal of Anatomy·Jill P J M HikspoorsWouter H Lamers
Mar 8, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mike K TerkelsenKim Ravnskjaer
Mar 11, 2021·Annals of Anatomy = Anatomischer Anzeiger : Official Organ of the Anatomische Gesellschaft·Sarah-Jane EstermannAndreas Reisinger
Apr 6, 2021·World Journal of Hepatology·Ramesh KumarRajeev Nayan Priyadarshi
Aug 3, 2021·JHEP Reports : Innovation in Hepatology·Yasuko Iwakiri, Jonel Trebicka

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