PMID: 7525696Jul 1, 1994Paper

The sinusoidal efflux of dibromosulfophthalein from rat liver is stimulated by albumin, ligandin and fatty acid binding protein but not by other dibromosulfophthalein binding proteins

Journal of Hepatology
H M NijssenG M Groothuis

Abstract

Organic anions can be excreted from the liver into the bile or back into the general circulation (sinusoidal efflux). It has previously been shown that the net sinusoidal efflux rate of dibromosulfophthalein from the perfused liver into the perfusate is the result of actual efflux from and reuptake into the liver, and can be strongly influenced by the presence of bovine serum albumin in the perfusion medium. The present study investigated whether the influence of albumin on the net sinusoidal efflux process is albumin-specific or whether other binding proteins could have a similar effect on the sinusoidal efflux. Using a single-pass liver perfusion technique and short-lasting (pulse) protein infusions, the stimulatory effect of a wide range of dibromosulfophthalein binding proteins on the sinusoidal efflux process were determined. These experiments showed that all the serum albumins tested as well as the liver cytosolic binding proteins fatty acid binding protein and ligandin (glutathione S-transferase) stimulated this process. The other proteins tested, bovine beta lactoglobulin-b, human gamma globulin and chicken egg lysozyme showed no stimulatory effect, despite relatively high equilibrium binding of dibromosulfophthalein. N...Continue Reading

References

Feb 1, 1992·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H M NijssenG M Groothuis
Sep 15, 1989·Biochemical Pharmacology·E L VansterkenburgL H Janssen
Jul 1, 1987·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·P van der SluijsD K Meijer
Mar 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R A Weisiger
Jan 1, 1985·Advances in Protein Chemistry·T Peters
Nov 1, 1983·The Journal of Clinical Investigation·E L Forker, B A Luxon
May 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R A WeisigerJ L Boyer
May 1, 1981·The Journal of Clinical Investigation·E L Forker, B A Luxon

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Citations

Oct 31, 2007·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M Baker, T Parton

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