The skeletal and cardiac alpha-actin genes are coexpressed in early embryonic striated muscle

Developmental Biology
C P Ordahl

Abstract

The relative steady-state abundance of cardiac and skeletal alpha-actin mRNAs at different stages of embryonic skeletal and cardiac (striated) muscle development was determined by a reverse transcriptase extension assay employing an single oligonucleotide primer complementary to a perfectly conserved region near the 5' end of both mRNAs. Both mRNAs were found to be present at every stage of embryonic striated muscle development tested, including the earliest assayable stages of limb muscle and cardiac muscle development. At early stages of skeletal muscle development the two mRNAs are present at similar levels while at later stages the abundance of the skeletal alpha-actin mRNA far exceeds that of the cardiac alpha-actin mRNA. Both mRNAs are also present at similar levels throughout embryonic cardiac muscle development while in adult cardiac muscle the cardiac alpha-actin mRNA predominates over the skeletal alpha-actin mRNA. These results for early embryonic striated muscle, in combination with previous results with late embryonic and adult striated muscle, indicate that both genes are coexpressed throughout striated muscle ontogeny. These two genes may not, therefore, be regulated under unique tissue-specific regulatory progra...Continue Reading

References

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Citations

Feb 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Y Sugi, J Lough
Apr 1, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·T ToyofukuB M Carlson
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May 1, 1988·Developmental Biology·C S Long, C P Ordahl
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Nov 15, 2011·Journal of Proteomics·Ruby P PonnuduraiShantanu Sengupta
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Mar 26, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Elisabeth EhlerJean-Claude Perriard
Jan 24, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Sara J VentersCharles P Ordahl
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