The SKM-1 leukemic cell line established from a patient with progression to myelomonocytic leukemia in myelodysplastic syndrome (MDS)-contribution to better understanding of MDS

Leukemia & Lymphoma
T Nakagawa, S Matozaki

Abstract

Although molecular and cytogenetic studies strongly point to the role of oncogenes, the mechanisms underlying the development of MDS and their progressive evolution to AML are still largely unknown. It has been postulated that AML has a preleukemic stage and a multi step pathogenesis, with the preleukemic stem cell able to undergo clonal evolution, with the acquisition of karyotypic abnormalities, leading to the development of acute leukemic subclones. The activations of the ras oncogenes or inactivation of the p53 anti-oncogene by point mutations have been described recently in several cases of MDS as well as AML, suggesting a critical role for these alterations in the development of these myelogenous leukemias. We reported previously establishment of a leukemic cell line, SKM-1, from the patient who initially possessed multiple point mutations of ras genes but lost these mutations during disease progression to myelomonocytic leukemia with acquisition of chromosomal abnormalities involving the p53 anti-oncogene. This process is characterized by genetic instabilities probably due to the failure of their DNA repairment leading to abnormal control of cell proliferation and differentiation. Studying this cell line, SKM-1, is a pro...Continue Reading

References

Aug 10, 1978·Nature·J T PrchalJ F Prchal
Aug 21, 1992·Cell·B Vogelstein, K W Kinzler
Feb 1, 1992·British Journal of Haematology·P FenauxJ P Kerckaert
Nov 22, 1991·Science·R A Weinberg
Jul 5, 1991·Science·M HollsteinC C Harris
Jun 1, 1991·The Journal of Clinical Investigation·H AhujaM Cline
Jun 6, 1991·Nature·A J LevineC A Finlay
Jul 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·E FeinsteinE Canaani
Jan 1, 1990·Genes & Development·D P Lane, S Benchimol
Nov 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D EliyahuM Oren
Aug 1, 1989·Baillière's Clinical Rheumatology·E L Semble, W C Wu
Jun 1, 1989·Blood Reviews·A Jacobs
Sep 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·H AhujaM J Cline
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J W JanssenC R Bartram
Mar 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C J FarrC J Marshall
Jan 1, 1987·Critical Reviews in Oncology/hematology·R H Sills
Mar 15, 1986·Cancer Genetics and Cytogenetics·R AbeS Kariyone
Aug 20, 1987·The New England Journal of Medicine·P J FialkowR Veith
Mar 18, 1994·Science·N PapadopoulosM D Adams
Oct 28, 1993·The New England Journal of Medicine·C C Harris, M Hollstein

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Citations

Jul 6, 2010·Nature Genetics·Thomas ErnstNicholas C P Cross
Mar 23, 2019·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Lei HuangRong Fu
Jun 9, 2020·Clinical and Translational Medicine·Ting-Juan ZhangJing-Dong Zhou
Jul 20, 2021·Biomedical Materials·Pavol ŠtefíkPeter Šiffalovič

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