The SLC34 family of sodium-dependent phosphate transporters

Pflügers Archiv : European journal of physiology
Carsten A WagnerJürg Biber

Abstract

The SLC34 family of sodium-driven phosphate cotransporters comprises three members: NaPi-IIa (SLC34A1), NaPi-IIb (SLC34A2), and NaPi-IIc (SLC34A3). These transporters mediate the translocation of divalent inorganic phosphate (HPO4 (2-)) together with two (NaPi-IIc) or three sodium ions (NaPi-IIa and NaPi-IIb), respectively. Consequently, phosphate transport by NaPi-IIa and NaPi-IIb is electrogenic. NaPi-IIa and NaPi-IIc are predominantly expressed in the brush border membrane of the proximal tubule, whereas NaPi-IIb is found in many more organs including the small intestine, lung, liver, and testis. The abundance and activity of these transporters are mostly regulated by changes in their expression at the cell surface and are determined by interactions with proteins involved in scaffolding, trafficking, or intracellular signaling. All three transporters are highly regulated by factors including dietary phosphate status, hormones like parathyroid hormone, 1,25-OH2 vitamin D3 or FGF23, electrolyte, and acid-base status. The physiological relevance of the three members of the SLC34 family is underlined by rare Mendelian disorders causing phosphaturia, hypophosphatemia, or ectopic organ calcifications.

References

Jun 1, 1992·The Journal of Nutrition·S M Borowitz, G S Granrud
Apr 1, 1988·The American Journal of Clinical Nutrition·S L Ash, B R Goldin
Apr 5, 1983·Biochimica Et Biophysica Acta·D FreemanB Ross
Jul 1, 1982·The Journal of Clinical Investigation·P C BrazyV W Dennis
Oct 1, 1982·Clinical Pharmacology and Therapeutics·M J BrodieB K Park
Jan 1, 1980·Advances in Experimental Medicine and Biology·P JaegerG Giebisch
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·S MagagninH Murer
Jan 15, 1997·The Journal of Membrane Biology·A HazamaE M Wright
Mar 21, 1998·Proceedings of the National Academy of Sciences of the United States of America·M F PfisterH Murer
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·L BeckH S Tenenhouse
Jul 3, 1998·The Journal of General Physiology·I ForsterH Murer
Aug 26, 1998·Methods in Enzymology·A Karlin, M H Akabas
Nov 17, 1998·Pflügers Archiv : European journal of physiology·A W JehleH Murer
Nov 25, 1998·Proceedings of the National Academy of Sciences of the United States of America·H HilfikerJ Biber
Feb 8, 2000·American Journal of Physiology. Renal Physiology·M TraebertB Kaissling
Mar 16, 2000·Proceedings of the National Academy of Sciences of the United States of America·Z Karim-JimenezH Murer
Jun 22, 2000·The Journal of Biological Chemistry·K KöhlerH Murer
Oct 4, 2000·Physiological Reviews·H MurerJ Biber
Dec 12, 2000·The Journal of Biological Chemistry·S M GislerH Murer
Aug 21, 2001·Pflügers Archiv : European journal of physiology·Z Karim-JimenezH Murer
Nov 20, 2001·Pflügers Archiv : European journal of physiology·D BacicH Murer
Feb 8, 2002·American Journal of Physiology. Cell Physiology·Hua XuFayez K Ghishan
Mar 7, 2002·American Journal of Physiology. Renal Physiology·Katja KöhlerHeini Murer
Mar 7, 2002·The Journal of Biological Chemistry·Hiroko SegawaKen-Ichi Miyamoto
Jul 18, 2002·American Journal of Physiology. Gastrointestinal and Liver Physiology·Kayo ArimaFayez K Ghishan
Aug 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·S ShenolikarE J Weinman
Aug 23, 2002·Proceedings of the National Academy of Sciences of the United States of America·Nati HernandoHeini Murer
Jan 9, 2003·Annual Review of Physiology·Heini MurerJürg Biber
Jul 10, 2003·Pflügers Archiv : European journal of physiology·Hiroko SegawaKen-Ichi Miyamoto
Aug 2, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Hua XuFayez K Ghishan
Dec 16, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Leila V VirkkiHeini Murer
Mar 5, 2004·American Journal of Physiology. Renal Physiology·Hiroko SegawaKen-ichi Miyamoto
Mar 23, 2004·Journal of the American Society of Nephrology : JASN·Sebastian BachmannThomas E Willnow
Nov 25, 2004·American Journal of Physiology. Renal Physiology·Hiroko SegawaKen-ichi Miyamoto
Dec 15, 2004·The Journal of General Physiology·Donald D F LooErnest M Wright

❮ Previous
Next ❯

Citations

Mar 4, 2017·International Journal of Cancer. Journal International Du Cancer·Hailiang FengYuqin Liu
Nov 13, 2017·Clinical and Experimental Nephrology·Kayo IkutaKen-Ichi Miyamoto
Feb 10, 2017·American Journal of Physiology. Cell Physiology·Sarah RatcliffeJonathan J Powell
Jan 10, 2018·Frontiers in Endocrinology·Osamu FujiiKen-Ichi Miyamoto
Dec 25, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Carsten A WagnerNati Hernando
Aug 16, 2018·Physiological Reviews·Toshimi MichigamiKeiichi Ozono
Jul 12, 2018·American Journal of Physiology. Renal Physiology·Noriko IdeBeate Lanske
Dec 5, 2018·Pflügers Archiv : European journal of physiology·Laurent Beck
Jan 24, 2019·Urolithiasis·Ben OliveiraStephen B Walsh
Mar 4, 2018·Nature Communications·Kevin W HuynhIra Kurtz
Jun 7, 2015·Journal of the American Society of Nephrology : JASN·Karl P SchlingmannMartin Konrad
Mar 2, 2017·Journal of the American Society of Nephrology : JASN·Linto ThomasCarsten A Wagner
Aug 25, 2015·Journal of Bone and Mineral Metabolism·Sawako TatsumiKen-Ichi Miyamoto
Dec 19, 2015·Physiological Reviews·Sylvia ChristakosGeert Carmeliet
Feb 5, 2019·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nadine KaeslerRafael Kramann
May 23, 2014·Current Opinion in Nephrology and Hypertension·Yves Sabbagh, Susan C Schiavi
Mar 20, 2020·Expert Opinion on Therapeutic Targets·Mario CozzolinoCarsten Alexander Wagner
Mar 11, 2020·Genes·Daniela Iancu, Emma Ashton
Sep 3, 2016·Endocrine Reviews·Peter J TebbenRajiv Kumar
Oct 14, 2017·The Journal of Clinical Endocrinology and Metabolism·Korcan DemirDaniella Magen
Aug 4, 2020·American Journal of Physiology. Renal Physiology·Linto ThomasTimo Rieg
Sep 4, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yasuhiro IchidaJürgen Floege
Aug 19, 2020·The FEBS Journal·Mattia D PizzagalliGiulio Superti-Furga
Oct 15, 2018·Clinical and Experimental Nephrology·Toru FujiiKen-Ichi Miyamoto
Jul 26, 2019·Physiological Reports·Natsuki MizutaniYasushi Okamura
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Meiheng SunFangfei Li
Apr 2, 2015·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Nati HernandoJürg Biber
Jun 13, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Elisa De PaolisEttore Capoluongo
Mar 29, 2020·The Journal of International Medical Research·Yuping MaJiaojiao Tan
Mar 29, 2020·Pflügers Archiv : European journal of physiology·Sarah E MottaCarsten A Wagner
Aug 29, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Carsten A WagnerNati Hernando
Jul 6, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dganit DinourCarsten A Wagner
Apr 12, 2019·Frontiers in Endocrinology·Toshimi Michigami, Keiichi Ozono
Dec 7, 2018·Pflügers Archiv : European journal of physiology·Ming Chang HuOrson W Moe

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Clinical Investigation
Stefan AmatschekRainer Oberbauer
Molecular Aspects of Medicine
I ForsterHeini Murer
The Journal of Steroid Biochemistry and Molecular Biology
Harriet S Tenenhouse
© 2021 Meta ULC. All rights reserved