The SLC6 transporters: perspectives on structure, functions, regulation, and models for transporter dysfunction

Pflügers Archiv : European journal of physiology
Gary RudnickFrançois Verrey

Abstract

The human SLC6 family is composed of approximately 20 structurally related symporters (co-transporters) that use the transmembrane electrochemical gradient to actively import their substrates into cells. Approximately half of the substrates of these transporters are amino acids, with others transporting biogenic amines and/or closely related compounds, such as nutrients and compatible osmolytes. In this short review, five leaders in the field discuss a number of currently important research themes that involve SLC6 transporters, highlighting the integrative role they play across a wide spectrum of different functions. The first essay, by Gary Rudnick, describes the molecular mechanism of their coupled transport which is being progressively better understood based on new crystal structures, functional studies, and modeling. Next, the question of multiple levels of transporter regulation is discussed by Reinhard Krämer, in the context of osmoregulation and stress response by the related bacterial betaine transporter BetP. The role of selected members of the human SLC6 family that function as nutrient amino acid transporters is then reviewed by François Verrey. He discusses how some of these transporters mediate the active uptake ...Continue Reading

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Citations

May 7, 2014·PloS One·Marta TorrenteFrançois Verrey
Dec 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Sijia WuHaley E Melikian
Oct 3, 2015·Worm·Kristin E Fenker, Gillian M Stanfield
Jun 4, 2016·Pflügers Archiv : European journal of physiology·Eleonora MargheritisElena Bossi
Apr 8, 2015·Biochimica Et Biophysica Acta·George Khelashvili, Harel Weinstein
Apr 23, 2014·Neurochemistry International·Randy D BlakelyMichael B Robinson
Aug 3, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Angélica Salatino-OliveiraMara H Hutz
Dec 7, 2014·The Journal of Physiology·Adriano GuetgFrançois Verrey
Apr 1, 2015·The Journal of Membrane Biology·Samantha L WillfordSepehr Eskandari
May 16, 2014·American Journal of Physiology. Renal Physiology·Eva S SchweikhardBirgitta C Burckhardt
Oct 2, 2019·The Journal of General Physiology·Gary Rudnick, Walter Sandtner
Dec 21, 2017·Current Protocols in Pharmacology·Shaili Aggarwal, Ole V Mortensen
Feb 7, 2020·PloS One·Bianca Maria RotoliValeria Dall'Asta
Aug 19, 2020·The FEBS Journal·Mattia D PizzagalliGiulio Superti-Furga
Oct 30, 2016·The Journal of Biological Chemistry·Susanne BracherHeinrich Jung
Dec 7, 2014·The Journal of Biological Chemistry·Esther Arribas-GonzálezBeatriz López-Corcuera
Jul 25, 2018·Biology Open·Janusz BoryczIan A Meinertzhagen
Jul 22, 2018·PloS One·Gabriel Núñez-VivancoMiguel Reyes-Parada
Dec 7, 2017·Journal of Molecular Microbiology and Biotechnology·Fereshteh Heidari TajabadiMilton H Saier
Oct 16, 2018·Frontiers in Molecular Neuroscience·Cristina Benito-MuñozBeatriz López-Corcuera
Jul 5, 2019·Nature Structural & Molecular Biology·Mary Hongying Cheng, Ivet Bahar
May 7, 2020·Asian Journal of Pharmaceutical Sciences·Chengliang HuLigong Chen
Mar 5, 2021·Proceedings of the National Academy of Sciences of the United States of America·Yuan-Wei ZhangGary Rudnick
Mar 29, 2019·Current Opinion in Structural Biology·Vikas Navratna, Eric Gouaux
Apr 2, 2021·Neuropharmacology·Andrés de la Rocha-MuñozBeatriz López-Corcuera
Aug 21, 2018·Neurochemistry International·Michael J TomlinsonRoxanne A Vaughan
May 19, 2021·ACS Chemical Neuroscience·Cristina Benito-MuñozBeatriz López-Corcuera

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