The Sleeping Remnant. Effect of Roux-En-Y Gastric Bypass on Plasma Levels of Gastric Biomarkers in Morbidly Obese Women: A Prospective Longitudinal Study

Obesity Surgery
Federico MarchesiF Di Mario

Abstract

Morpho-functional modifications of the gastric remnant after Roux-en-Y gastric bypass (RYGB) have not been completely defined, due to its inaccessibility for bioptic mapping. The aim of the study is to evaluate such modifications using Gastropanel®, a non-invasive blood test cross-checking four gastric biomarkers, able to provide a snapshot of mucosa conditions. Twenty-four women undergoing RYGB were prospectively enrolled. Gastropanel® parameters (pepsinogens, Gastrin-17 and immunoglobulins against Helicobacter pylori), biometrical/clinical data were collected preoperatively and at 6-months follow-up. All parameters showed significant reduction (p < 0.05). Pepsinogen I reduction correlated with BMI percent decrease. The exclusion of food transit is responsible for significant drop in gastric output, hardly representing a risk factor in the remnant carcinogenesis, being unexposed to alimentary carcinogenic agents.

References

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Oct 17, 2007·Archives of Surgery·Harutaka InoueJacques Marescaux
Jul 12, 2014·European Journal of Gastroenterology & Hepatology·Adrian G McNichollUNKNOWN Helicobacter pylori Study Group of Asociación Española de Gastroenterología (AEG)
Sep 23, 2014·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Giulio OrlandoAlessandro Puzziello
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Nov 2, 2016·Gut·P MalfertheinerUNKNOWN European Helicobacter and Microbiota Study Group and Consensus panel

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