The slit receptor Rig-1/Robo3 controls midline crossing by hindbrain precerebellar neurons and axons

Neuron
Valérie MarillatAlain Chédotal

Abstract

During development, precerebellar neurons migrate dorsoventrally from the rhombic lip to the floor plate. Some of these neurons cross the midline while others stop. We have identified a role for the slit receptor Rig-1/Robo3 in directing this process. During their tangential migration, neurons of all major hindbrain precerebellar nuclei express high levels of Rig-1 mRNA. Rig-1 expression is rapidly downregulated as their leading process crosses the floor plate. Interestingly, most precerebellar nuclei do not develop normally in Rig-1-deficient mice, as they fail to cross the midline. In addition, inferior olivary neurons, which normally send axons into the contralateral cerebellum, project ipsilaterally in Rig-1 mutant mice. Similarly, neurons of the lateral reticular nucleus and basilar pons are unable to migrate across the floor plate and instead remain ipsilateral. These results demonstrate that Rig-1 controls the ability of both precerebellar neuron cell bodies and their axons to cross the midline.

References

Nov 15, 1991·The Journal of Comparative Neurology·F Bourrat, C Sotelo
Jan 1, 1990·Anatomy and Embryology·K Ono, K Kawamura
Mar 9, 1989·Nature·M Schwanzel-Fukuda, D W Pfaff
Jan 1, 1973·Progress in Brain Research·E T Pierce
Nov 15, 1996·Science·M Tessier-Lavigne, C S Goodman
Feb 5, 1999·Progress in Brain Research·E T Stoeckli
Apr 10, 1999·Neuron·K T Nguyen Ba-CharvetA Chédotal
Oct 31, 2000·Neuron·C I Rodriguez, S M Dymecki
Nov 21, 2000·Current Opinion in Neurobiology·T M Jessell, J R Sanes
Feb 17, 2001·Current Opinion in Neurobiology·R J Wingate
Jun 21, 2001·Molecular and Cellular Neurosciences·K T Nguyen-Ba-CharvetA Chédotal
Nov 21, 2001·Nature Reviews. Neuroscience·O Marín, J L Rubenstein
Dec 26, 2001·The Journal of Comparative Neurology·Valérie MarillatAlain Chédotal
Jan 24, 2002·Neuron·Lara D Hutson, Chi Bin Chien
Jun 8, 2002·Developmental Biology·Frédéric CauseretEvelyne Bloch-Gallego
Aug 30, 2002·Current Opinion in Genetics & Development·Kit WongYi Rao
Nov 2, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Yan Zhu, Sarah Guthrie
Dec 10, 2002·Science·Barry J Dickson

❮ Previous
Next ❯

Citations

Dec 21, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Martin M MortazaviNicholas Theodore
Dec 22, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Martin M MortazaviNicholas Theodore
Aug 23, 2005·Brain Research. Brain Research Reviews·Evelyne Bloch-GallegoMatías Hidalgo-Sánchez
Aug 4, 2010·Nature Neuroscience·Julien BouvierGilles Fortin
Jul 22, 2006·Nature Reviews. Neuroscience·Noam Y Harel, Stephen M Strittmatter
Apr 26, 2006·Oncogene·T E Werbowetski-OgilvieR F Del Maestro
Apr 16, 2009·Cerebral Cortex·Melissa BarberJohn G Parnavelas
Mar 20, 2010·Cold Spring Harbor Perspectives in Biology·Elizabeth C Engle
Apr 25, 2012·Development, Growth & Differentiation·Mitsuhiro Hashimoto, Masahiko Hibi
Jan 6, 2005·Molecular and Cellular Biology·George Steele-PerkinsRichard M Gronostajski
Nov 13, 2012·Neural Development·Melanie PhilippEsther T Stoeckli
Mar 15, 2006·Neuro-oncology·Tiziana PiepoliGaetano Finocchiaro
Aug 23, 2012·Development·Anna CariboniJohn G Parnavelas
Mar 17, 2010·PLoS Biology·Nicolas RenierAlain Chédotal
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Doyeun Kim, Susan L Ackerman
Apr 2, 2014·Journal of Visualized Experiments : JoVE·Miguel TilloChristiana Ruhrberg
Jun 28, 2014·Journal of AAPOS : the Official Publication of the American Association for Pediatric Ophthalmology and Strabismus·Arif O Khan, Khaled Abu-Amero
Feb 24, 2006·Pediatric Research·Elizabeth C Engle
Oct 10, 2008·AJNR. American Journal of Neuroradiology·P Jissendi-TchofoA J Barkovich
Oct 6, 2004·Médecine sciences : M/S·Vieri FailliAlain Chédotal
Jan 15, 2015·Developmental Cell·Ian V Beamish, Timothy E Kennedy
Sep 29, 2011·Gene Expression Patterns : GEP·Stephanie M FreerStephen T Crews
May 3, 2011·Current Opinion in Genetics & Development·Hosung JungChristine E Holt
Jan 19, 2011·Molecular and Cellular Neurosciences·Kazuhiko NishidaFujio Murakami
Jan 15, 2010·Magnetic Resonance Imaging·Ashwin AvadhaniS Rajasekaran
Sep 26, 2009·Seminars in Pediatric Neurology·Kimberly A AldingerKathleen J Millen
May 12, 2009·Neuroscience Research·Haruyasu Watanabe, Fujio Murakami
Aug 21, 2007·Experimental Neurology·Gabrielle Curinga, George M Smith
Feb 6, 2007·Current Opinion in Neurobiology·Charlotta LindwallLinda J Richards
Nov 3, 2005·The European Journal of Neuroscience·Rosine WehrleIsabelle Dusart
Jan 27, 2007·Journal of Neurochemistry·Gabriele Loers, Melitta Schachner
Aug 21, 2007·The Journal of Comparative Neurology·David M HowellPeter H Mathers
Jun 8, 2007·Journal of Anatomy·William D AndrewsJohn G Parnavelas
Dec 25, 2008·The Journal of Comparative Neurology·Asli KumbasarE David Litwack
Jan 25, 2006·The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology·Reha S ErzurumluMark F Jacquin
Nov 11, 2010·Annals of the New York Academy of Sciences·Tracy J Dixon-Salazar, Joseph G Gleeson
Jun 23, 2011·Clinical Genetics·L Izzi, F Charron
May 4, 2013·The Journal of Comparative Neurology·Masaki ShinoharaFujio Murakami

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.

Axon Guidance

Axon guidance is a complex neural developmental field that investigates mechanisms through which neurons send out axons to reach its target. Here is the latest research in this domain.