PMID: 7539840Feb 15, 1995Paper

The slow Ca(2+)-activated K+ current, IAHP, in the rat sympathetic neurone

The Journal of Physiology
Oscar SacchiRita Canella

Abstract

1. Adult and intact sympathetic neurones of the rat superior cervical ganglion maintained in vitro at 37 degrees C were analysed using the two-electrode voltage-clamp technique in order to investigate the slow component of the Ca(2+)-dependent K+ current, IAHP. 2. The relationship between the after-hyperpolarization (AHP) conductance, gAHP, and estimated Ca2+ influx resulting from short-duration calcium currents evoked at various voltages proved to be linear over a wide range of injected Ca2+ charge. An inflow of about 1.7 x 10(7) Ca2+ ions was required before significant activation of gAHP occurred. After priming, the gAHP sensitivity was about 0.3 nS pC-1 of Ca2+ inward charge. 3. IAHP was repeatedly measured at different membrane potentials; its amplitude decreased linearly with membrane hyperpolarization and was mostly abolished close to the K+ reversal potential, EK (-93 mV). The monoexponential decay rate of IAHP was a linear function of total Ca2+ entry and was not significantly altered by membrane potential in the -40 to -80 mV range. 4. Voltage-clamp tracings of IAHP could be modelled as a difference between two exponentials with tau on approximately 5 ms and tau off = 50-250 ms. 5. Sympathetic neurones discharged only...Continue Reading

Citations

Feb 3, 2006·Journal of Neurophysiology·Oscar SacchiRiccardo Fesce
May 19, 2006·Journal of Neurophysiology·Jason A Luther, Susan J Birren
Dec 23, 2003·The European Journal of Neuroscience·Fivos VogalisBarrie Lancaster
Dec 18, 2019·Brain Research·Nathalia Maria Silva-Dos-SantosJosé Henrique Leal-Cardoso

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