The small peptide world in long noncoding RNAs

Briefings in Bioinformatics
Seo-Won ChoiJin-Wu Nam

Abstract

Long noncoding RNAs (lncRNAs) are a group of transcripts that are longer than 200 nucleotides (nt) without coding potential. Over the past decade, tens of thousands of novel lncRNAs have been annotated in animal and plant genomes because of advanced high-throughput RNA sequencing technologies and with the aid of coding transcript classifiers. Further, a considerable number of reports have revealed the existence of stable, functional small peptides (also known as micropeptides), translated from lncRNAs. In this review, we discuss the methods of lncRNA classification, the investigations regarding their coding potential and the functional significance of the peptides they encode.

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Methods Mentioned

BETA
immunoprecipitation
RNA-seq
Ribo-seq
Ribo-seqs
GTI-seq

Software Mentioned

ID
PhyloCSF
CPAT
Linc
Rp
RibORF
PROTEOFORMER
RiboTaper
ORF
SPECtre

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