Dec 15, 2017

The small vesicular culprits: the investigation of extracellular vesicles as new targets for cancer treatment

Clinical and Translational Medicine
Fumihiko UrabeTakahiro Ochiya

Abstract

Extracellular vesicles (EVs) are membranous vesicles released from almost all type of cells including cancer cells. EVs transfer their components, such as microRNAs (miRNAs), messenger RNAs, lipids and proteins, from one cell to another, affecting the target cells. Emerging evidence suggests that reciprocal interactions between cancer cells and the cells in their microenvironment via EVs drive disease progression and therapy resistance. Therefore, understanding the roles of EVs in cancer biology will provide us with new opportunities to treat patients. EVs are also useful for monitoring disease processes. EVs have been found in many kinds of biological fluids such as blood, urine, saliva and semen. Because of their accessibility, EVs offer ease of collection with minimal discomfort to patients and are preferred for serial collection. In addition, they reflect and carry dynamic changes in disease, allowing us to access crucial molecular information about the disease status. Therefore, EVs hold great possibility as clinically useful biomarkers to provide multiple non-invasive snapshots of primary and metastatic tumors. In this review, we summarize current knowledge of miRNAs in EVs in cancer biology and as biomarkers. Furthermore...Continue Reading

  • References133
  • Citations2

References

  • References133
  • Citations2

Mentioned in this Paper

Biological Markers
Seminal Fluid
Urine
Dermatofibrosarcoma Protuberans
Tissue Membrane
Extracellular
Saliva - SpecimenType
Semen
NOS Activity (Molecular Function)
Vesicle

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