The smell of renal protection against chronic kidney disease: Hydrogen sulfide offers a potential stinky remedy

Pharmacological Reports : PR
George J Dugbartey

Abstract

Chronic kidney disease (CKD) is a common global health challenge characterized by irreversible pathological processes that reduce kidney function and culminates in development of end-stage renal disease. It is associated with increased morbidity and mortality in addition to increased caregiver burden and higher financial cost. A central player in CKD pathogenesis and progression is renal hypoxia. Renal hypoxia stimulates induction of oxidative and endoplasmic reticulum stress, inflammation and tubulointerstitial fibrosis, which in turn, promote cellular susceptibility and further aggravate hypoxia, thus forming a pathological vicious cycle in CKD progression. Although the importance of CKD is widely appreciated, including improvements in the quality of existing therapies such as dialysis and transplantation, new therapeutic options are limited, as there is still increased morbidity, mortality and poor quality of life among CKD patients. Growing evidence indicates that hydrogen sulfide (H2S), a small gaseous signaling molecule with an obnoxious smell, accumulates in the renal medulla under hypoxic conditions, and functions as an oxygen sensor that restores oxygen balance and increases medullary flow. Moreover, plasma H2S level h...Continue Reading

References

Feb 1, 1984·Kidney International·R J McGonigleJ W Fisher
Feb 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G WolfR A Stahl
Jan 1, 1996·Free Radical Biology & Medicine·I Ceballos-PicotB Descamps-Latscha
Jan 3, 2001·Kidney International·W J WelchC S Wilcox
Sep 22, 2001·The New England Journal of Medicine·E J LewisUNKNOWN Collaborative Study Group
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Christian RosenbergerKai-Uwe Eckardt
Dec 20, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael S WiesenerKai-Uwe Eckardt
Jun 17, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Francesco LocatelliCarmine Zoccali
Mar 23, 1957·Nature·L O JACOBSONL PLZAK
Oct 9, 2003·Kidney International. Supplement·Roger N GreenwoodNathan W Levin
Dec 31, 2003·Hypertension·Francisca RodriguezAlberto Nasjletti
Feb 12, 2004·Kidney International·Krissanapong ManothamMasaomi Nangaku
Apr 22, 2004·Journal of the American Society of Nephrology : JASN·Krissanapong ManothamMasaomi Nangaku
Nov 25, 2004·Diabetes·Sergiu-Bogdan CatrinaLorenz Poellinger
Dec 16, 2004·American Journal of Physiology. Heart and Circulatory Physiology·William J WelchChristopher S Wilcox
Apr 23, 2005·Science·Eric BlackstoneMark B Roth
Jul 29, 2005·American Journal of Physiology. Renal Physiology·Chunhua CaoThomas L Pallone
Aug 30, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Tetsuhiro TanakaMasaomi Nangaku
Dec 24, 2005·Proceedings of the National Academy of Sciences of the United States of America·Michal SafranWilliam G Kaelin
Jul 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Fady T Botros, L Gabriel Navar
Oct 7, 2006·The Journal of Experimental Biology·Kenneth R OlsonJane A Madden
Feb 27, 2007·The American Journal of Pathology·Wanja Michael BernhardtKai-Uwe Eckardt
Apr 14, 2007·The Journal of Biological Chemistry·Guangdong YangRui Wang
Oct 5, 2007·Kidney International·C RosenbergerS N Heyman
Oct 24, 2007·Proceedings of the National Academy of Sciences of the United States of America·Gloria A BenavidesDavid W Kraus
Oct 31, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Shuichi OhtomoToshio Miyata
Aug 1, 2008·American Journal of Physiology. Renal Physiology·Kuniko KimuraYoshihiko Saito
Aug 6, 2008·Laboratory Investigation; a Journal of Technical Methods and Pathology·Pinpat TripataraChristoph Thiemermann
Nov 7, 2008·Journal of the American Society of Nephrology : JASN·Elisabeth M ZeisbergRaghu Kalluri
Feb 28, 2009·The Journal of Pharmacology and Experimental Therapeutics·Min XiaNingjun Li
May 2, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Joshua ZaritskyIsidro B Salusky
May 15, 2009·American Journal of Physiology. Renal Physiology·Zhibin XuKarmin O
May 29, 2009·American Journal of Physiology. Renal Physiology·Utpal SenSuresh C Tyagi
Jul 18, 2009·Circulation Research·John W CalvertDavid J Lefer
Aug 6, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Alessandra F PernaNatale G De Santo
Aug 15, 2009·Science·Chiara VecchiAntonello Pietrangelo
Sep 10, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Young Rim SongKi Young Na

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Citations

Aug 24, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nicholas M SelbySteven Sourbron
Nov 26, 2019·Chinese Medical Journal·Yu WangQiong-Jing Yuan
Jun 10, 2020·American Journal of Physiology. Cell Physiology·Guangdong Yang
Jan 4, 2019·International Urology and Nephrology·Fikriye Yasemin OzatikZeynep Bayat
Jan 17, 2019·International Journal of Molecular Sciences·Xu CaoJinsong Bian
Dec 20, 2019·Chinese Medical Journal·Yu WangQiong-Jing Yuan
Aug 18, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Joana Claudio PierettiAmedea Barozzi Seabra
Aug 8, 2021·International Journal of Molecular Sciences·Chien-Ning Hsu, You-Lin Tain
Aug 28, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·George J DugbarteyAlp Sener

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