The smoothness index, but not the trough-to-peak ratio predicts changes in carotid artery wall thickness during antihypertensive treatment

Journal of Hypertension
D RizzoniE A Rosei

Abstract

It has recently been demonstrated that the smoothness index (SI) (the ratio between the average of the blood pressure changes computed for each hour of the recording and its standard deviation), a new and reproducible measure of the homogeneity of blood pressure reduction by antihypertensive treatment, has evident advantages over trough-to-peak ratio (T/P) in the prediction of the regression of left ventricular hypertrophy. Therefore we considered it to be worthwhile to compare the ability of SI and T/P to predict changes of the carotid artery intima-media thickness (IMT) during pharmacological treatment in patients with essential hypertension. In 100 patients with essential hypertension, 24 h ambulatory blood pressure and carotid artery IMT were measured after 3 weeks of therapeutic wash-out and after 12 months of antihypertensive treatment (calcium antagonists, diuretics, angiotensin converting enzyme (ACE) inhibitors or beta-blockers). The homogeneity of the effect of treatment over blood pressure was evaluated by computing T/P and SI. Twenty-four hour blood pressure was significantly reduced by therapy, while, on average, a small but significant increase in indices of carotid artery wall thickness was observed. However, IMT...Continue Reading

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Citations

Jul 7, 2011·International Urology and Nephrology·Mehmet KanbayAdrian Covic
Mar 28, 2013·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Josep Redon
Oct 1, 2008·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Gianfranco ParatiGiuseppe Mancia
Sep 22, 2012·High Blood Pressure & Cardiovascular Prevention : the Official Journal of the Italian Society of Hypertension·Valentina TrimarcoRaffaele Izzo
Sep 21, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Philippe Gosse, Helmut Schumacher
Dec 7, 2013·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Gianfranco Parati, Helmut Schumacher
Jun 20, 2014·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Grzegorz BiloGianfranco Parati
Jul 1, 2008·Journal of the American Society of Hypertension : JASH·Gordon McInnes
Oct 13, 2014·Orvosi hetilap·Ede Kékes, István Kiss
Mar 21, 2015·Current Hypertension Reports·Gianfranco ParatiGrzegorz Bilo
Jun 26, 2013·Archives of Physical Medicine and Rehabilitation·Julien MetrotIsabelle Laffont
Jul 29, 2005·The American Journal of Chinese Medicine·Sang Pil YunHyung Sup Bae
Apr 12, 2005·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Gianfranco Parati
Apr 26, 2003·Journal of Hypertension·Faiez ZannadGianfranco Parati
Jan 13, 2004·Journal of Cardiovascular Pharmacology·Emilio KuschnirGilbert Wagener
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May 2, 2014·Journal of Hypertension·George S StergiouAngeliki Ntineri

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