The SNPs in pre-miRNA are related to the response of capecitabine-based therapy in advanced colon cancer patients

Oncotarget
Yong MaoDong Hua

Abstract

The single nucleotide polymorphisms (SNPs) in the microRNA precursor (pre-miRNA) may modulate the posttranscriptional regulation of gene expression and explain individual sensitivity to chemotherapy. Here we investigated the correlation between 23 SNPs in the pre-miRNA and the efficacy of capecitabine-based chemotherapy in 274 advanced colon cancer patients. Statistical analysis indicated that much more patients with rs744591 A/C(48.03%), C/C (53.45%) or C allele (49.73%) responded to the chemotherapy than those with the A/A genotype (33.71%). The response rates of rs745666 G/C heterozygous patients (35.25%) and C allele carriers (39.69%) were apparently less than that of the G/G homozygous patients (56.25%). Moreover, three SNPs rs2114358, rs35770269, and rs73239138 were significantly associated with the occurrence of side effects of chemotherapy. The patients with rs2114358 C allele (OR = 2.016) or rs35770269 T allele (OR = 2.299) were much more prone to endure adverse events. However, the incidence of side effect was lower in the patients carrying rs73239138 A allele than those with G/G genotype (OR = 0.500). Our findings demonstrate that genetic variations in pre-miRNA may influence the efficacy of capecitabine-based chemot...Continue Reading

References

Mar 4, 2008·Molecular Cancer Research : MCR·Konrad HuppiNatasha J Caplen
Apr 21, 2009·Pharmacogenomics·Grace S Y PangCaroline G L Lee
May 7, 2011·Pharmacogenetics and Genomics·Katrin SangkuhlRuss B Altman
Jun 10, 2011·Trends in Molecular Medicine·Jakob Lewin Rukov, Noam Shomron
Nov 24, 2011·The Journal of Biological Chemistry·Anthony M BarsottiCarol Prives
May 1, 2012·The British Journal of Dermatology·M SandF G Bechara
May 1, 2012·Cell·Margaret S Ebert, Phillip A Sharp
Mar 20, 2013·FEBS Letters·Li-Jun MiaoJing Wang
Jul 23, 2014·BMC Cancer·Maria Peña-ChiletGloria Ribas
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Feb 7, 2015·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ursula AmstutzCarlo R Largiadèr
Jan 20, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Shegan GaoXiaoshan Feng
Jan 26, 2016·International Journal of Cancer. Journal International Du Cancer·Didier MeulendijksJan H M Schellens
Jan 26, 2016·CA: a Cancer Journal for Clinicians·Wanqing ChenJie He
Dec 7, 2016·Nature Reviews. Clinical Oncology·Cornelis J A PuntLouis Vermeulen
Jun 20, 2017·Pharmacogenetics and Genomics·Angela Gutierrez-CaminoMarry M van den Heuvel-Eibrink

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping
PCR
chips

Software Mentioned

TargetScan
SPSS11

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.