The SOCS box protein STOPS is required for phototransduction through its effects on phospholipase C

Neuron
Tao WangC Montell

Abstract

Phosphoinositide-specific phospholipase C (PLC) isozymes play roles in a diversity of processes including Drosophila phototransduction. In fly photoreceptor cells, the PLCbeta encoded by norpA is critical for activation of TRP channels. Here, we describe a PLCbeta regulator, STOPS, which encodes a SOCS box protein. Mutation of stops resulted in a reduced concentration of NORPA and a defect in stopping signaling following cessation of the light stimulus. NORPA has been proposed to have dual roles as a PLC- and GTPase-activating protein (GAP). We found that the slow termination resulting from expressing low levels of wild-type NORPA was suppressed by addition of normal amounts of an altered NORPA, which had wild-type GAP activity, but no PLC activity. STOPS is the first protein identified that specifically regulates PLCbeta protein concentration. Moreover, this work demonstrates that a PLCbeta derivative that does not promote TRP channel activation, still contributes to signaling in vivo.

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Citations

Aug 27, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kartik VenkatachalamCraig Montell
Jan 31, 2012·Journal of Neurogenetics·Randall D Shortridge
Sep 2, 2009·The Journal of Cell Biology·Tao WangBruce A Edgar
Apr 14, 2012·Trends in Neurosciences·Craig Montell
Jan 11, 2008·Neuron·Patrick Dolph
May 10, 2018·Molecular Biology of the Cell·Haifang ZhaoTao Wang
Jul 13, 2019·Genome Biology and Evolution·Aide Macias-MuñozAdriana D Briscoe

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