The sodium-iodide symporter

Current Drug Targets. Immune, Endocrine and Metabolic Disorders
C H Baker, J C Morris

Abstract

The sodium-iodide symporter (NIS) is an intrinsic plasma membrane protein that mediates active transport of iodide in the thyroid gland and several other extra-thyroidal tissues. This activity has been utilized for many years for imaging the thyroid gland and for treatment of thyroid disease both benign and malignant. Cloning and characterization of NIS has more recently allowed research into its use in non-thyroidal cancers through gene transfer for both diagnosis and treatment.

Citations

Jul 23, 2014·Best Practice & Research. Clinical Endocrinology & Metabolism·Luca GiovanellaGiorgio Treglia
Dec 5, 2009·Critical Reviews in Clinical Laboratory Sciences·Xiao Hong LiuC Andrew van Hasselt
Dec 22, 2012·Expert Opinion on Biological Therapy·Céline GiordanoMarc Ruel
Dec 7, 2013·Endocrine Reviews·Carla PortulanoNancy Carrasco
Aug 9, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Luca GiovanellaEly Wolin

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