The Soluble Plasminogen Activator Receptor as a Biomarker on Monitoring the Therapy Progress of Pulmonary TB-AFB(+) Patients.

Tuberculosis Research and Treatment
Tri Yudani Mardining Raras, Iin Noor Chozin

Abstract

The role of soluble soluble urokinase-type plasminogen activator receptor (suPAR) as a biological marker for TB treatment efficacy on active pulmonary TB-AFB(+) patients was investigated. Twenty pulmonary TB-AFB(+) patients participated in a cohort study for six months. The plasma suPAR level was measured using ELISA method before treatment, two months, four months and six months after treatment. At the same time clinical parameters were also measured. Results indicated that all patients (n = 20) showed highest plasma suPAR levels before treatment (median 12.775 ng/mL) and significantly decreased ( P = .0001<.05, R(2) = .890) after 2 months (median 8.019 ng/mL) and 4 months (median 5.771 ng/mL) of treatment, respectively. However, only slightly declined after 6 months therapy (median 5.009 ng/mL), near control group level (median 4.772 ng/mL). Interestingly, the significant reduced of suPAR level was parallel to treatment efficacy and correlated with other clinical and laboratory parameters, that is, decreasing of patients' complaints, increasing of BMI (r = -0.281), thoracic imaging improvement, sputum conversion, decreasing of ESR (r = 0.577) and monocytes count (r = 0.536) with exception the width of lesion in thoracic imagi...Continue Reading

References

Jun 14, 2000·American Journal of Respiratory and Critical Care Medicine·P F Barnes, B Wizel
Apr 5, 2002·Clinical Microbiology Reviews·Reinout van CrevelJos W M van der Meer
Apr 21, 2007·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Joel Fleury Djoba SiawayaGerhard Walzl
Sep 4, 2009·Tropical Medicine & International Health : TM & IH·Paulo RabnaJesper Eugen-Olsen

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Citations

Jan 11, 2013·Tuberculosis Research and Treatment·Tri Yudani Mardining RarasIin Noor Chozin

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Methods Mentioned

BETA
ELISA
ESR

Software Mentioned

SAS
SPSS

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