The solution structures of epidermal growth factor and transforming growth factor alpha

Progress in Growth Factor Research
I D CampbellM J Tappin

Abstract

The structures of human epidermal growth factor (EGF) and human transforming growth factor alpha (TGF alpha) have been determined in solution using nuclear magnetic resonance techniques. The features of each structure are described and similarities and differences between them are discussed. The structures are combined with information from sequence homologies to produce a model of the receptor-recognition sites of EGF and TGF alpha, which can be tested in a site-directed mutagenesis programme. The model assists in explaining previous observations of sequence-activity relationships. The TGF alpha and EGF structures also serve as models for homologous modules in other extracellular proteins.

References

May 5, 1979·Journal of Molecular Biology·R RicharzK Wüthrich
May 31, 1985·Biochemical and Biophysical Research Communications·J J NestorA B Schreiber
Aug 1, 1985·Cell·P StroobantM D Waterfield
Jan 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·J StenfloB Dahlbäck
Jan 1, 1987·Annual Review of Biochemistry·G Carpenter
Sep 5, 1988·Journal of Molecular Biology·C M Wilmot, J M Thornton
Jul 12, 1988·Biochemistry·A W BurgessE C Nice
Feb 1, 1988·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·R M Cooke, I D Campbell
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J P TamL Ossowski
May 3, 1987·Nature·R M CookeB Sheard
Aug 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·G T MontelioneH A Scheraga
Aug 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·H MarquardtG J Todaro
Mar 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A KomoriyaJ Schlessinger

❮ Previous
Next ❯

Citations

Jan 1, 1992·Protein Science : a Publication of the Protein Society·M BaronI D Campbell
Dec 1, 1990·Journal of Neuro-oncology·J CapalaJ Carlsson
Jan 1, 1990·Progress in Growth Factor Research·E J van Zoelen
Jul 11, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kazuya MaedaYuichi Sugiyama
May 15, 2003·Nuclear Medicine and Biology·Asa Liljegren SundbergLars Gedda
Jan 1, 1991·Journal of Receptor Research·M PråhlL Sjödin
Nov 13, 1990·European Journal of Biochemistry·R M CookeF Inagaki
Jul 1, 1992·Medicinal Research Reviews·M D Walkinshaw
Feb 15, 1994·International Journal of Cancer. Journal International Du Cancer·P OlssonJ Carlsson
Jul 1, 1996·Pathology, Research and Practice·E J van ZoelenM L van de Poll
May 3, 1996·Biochemical Pharmacology·D E Davies, S G Chamberlin
Oct 22, 2013·Progress in Biophysics and Molecular Biology·Rajesh N Gacche, Rohan J Meshram
Jan 1, 1997·Biopolymers·C McInnes, B D Sykes
Jun 15, 1991·European Journal of Biochemistry·T S HarveyI D Campbell
Jun 3, 2006·Protein Engineering, Design & Selection : PEDS·Jennifer R CochranK Dane Wittrup
May 29, 1991·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I D Campbell, M Baron
Mar 30, 2001·The Journal of Biological Chemistry·L StrachanK D Kumble
Jun 28, 1996·The Journal of Biological Chemistry·S M PuddicombeD E Davies
Jun 6, 1998·The Journal of Biological Chemistry·Y AbeD Kohda
Feb 1, 1992·International Journal of Peptide and Protein Research·L O NarhiK R Westcott
Jul 5, 2001·The Journal of Biological Chemistry·H S LuR C Bi
Feb 1, 1992·International Journal of Peptide and Protein Research·T P Kline, L Mueller
Sep 1, 1991·International Journal of Peptide and Protein Research·J P TamJ W Zhang
May 29, 2002·Biochimica Et Biophysica Acta·Jemma LawsonAndrew J Dunbar
Aug 30, 1994·International Journal of Radiation Oncology, Biology, Physics·J CarlssonP Olsson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.