The somatic mutation theory of cancer: growing problems with the paradigm?

BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology
Ana M Soto, Carlos Sonnenschein

Abstract

The somatic mutation theory has been the prevailing paradigm in cancer research for the last 50 years. Its premises are: (1) cancer is derived from a single somatic cell that has accumulated multiple DNA mutations, (2) the default state of cell proliferation in metazoa is quiescence, and (3) cancer is a disease of cell proliferation caused by mutations in genes that control proliferation and the cell cycle. From this compelling simplicity, an increasingly complicated picture has emerged as more than 100 oncogenes and 30 tumor suppressor genes have been identified. To accommodate this complexity, additional ad hoc explanations have been postulated. After a critical review of the data gathered from this perspective, an alternative research program has been proposed. It is based on the tissue organization field theory, the premises of which are that carcinogenesis represents a problem of tissue organization, comparable to organogenesis, and that proliferation is the default state of all cells. The merits of these competing theories are evaluated herein.

References

Feb 1, 1976·Proceedings of the National Academy of Sciences of the United States of America·K Illmensee, B Mintz
Jun 1, 1991·Environmental Health Perspectives·B M MechlerI Török
Oct 1, 1991·British Journal of Cancer·W H Clark
Aug 1, 1985·Cell·J M Bishop
Jan 1, 1987·Journal of Cell Science. Supplement·M J Bissell, M H Barcellos-Hoff
Nov 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·M A DiBerardinoR G McKinnell
Jul 1, 1985·Journal of Steroid Biochemistry·A M Soto, C Sonnenschein
Oct 1, 1967·The Journal of Pathology and Bacteriology·R A Willis
Jan 1, 1983·Progress in Nucleic Acid Research and Molecular Biology·G M Cooper
Oct 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T A Stewart, B Mintz
Feb 1, 1980·Journal of the National Cancer Institute·C Sonnenschein, A M Soto
May 5, 1995·Science·R ParsonsB Vogelstein
Dec 10, 1993·Science·B RubinfeldP Polakis
Jan 1, 1995·Advances in Cancer Research·A G Knudson
Oct 18, 1996·Cell·K W Kinzler, B Vogelstein
Oct 1, 1996·The Journal of Steroid Biochemistry and Molecular Biology·C SonnenscheinC L Michaelson
Jun 17, 1998·Genes & Development·E Robanus-MaandagH te Riele
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·K D McCulloughJ W Grisham
Feb 2, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·J Bard
Feb 2, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·A D de Grey
Sep 7, 2000·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S F Gilbert, S Sarkar
Feb 15, 2001·Molecular Carcinogenesis·C Sonnenschein, A M Soto
Mar 10, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P T IauR W Blamey
Jun 5, 2001·Nature Reviews. Genetics·K R Benson
Feb 28, 2002·Proceedings of the National Academy of Sciences of the United States of America·Tian-Li WangVictor E Velculescu
Mar 20, 2002·Nature Reviews. Cancer·M J Bissell, D Radisky
Jun 5, 2002·Nature Reviews. Cancer·William C Hahn, Robert A Weinberg
Jul 6, 2002·Science·I Bernard Weinstein
Nov 15, 2002·The New England Journal of Medicine·William C Hahn, Robert A Weinberg
Jan 1, 2003·Cell·Tyler Jacks, Robert A Weinberg
Jul 16, 2003·Trends in Immunology·Isharat Yusuf, David A Fruman
Mar 10, 1962·Lancet·D W SMITHERS
Jan 16, 2004·Nature·Henry Harris

❮ Previous
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Citations

Jan 3, 2006·Journal of Biosciences·Edna Cukierman
Feb 22, 2008·Acta Biotheoretica·M BizzarriF D'Anselmi
Sep 15, 2010·Cancer Metastasis Reviews·Leanne C Huysentruyt, Thomas N Seyfried
Oct 24, 2012·Cancer Metastasis Reviews·Giovanna ZappalàSteve W Cole
May 12, 2005·Journal of Mammary Gland Biology and Neoplasia·Robert B Clarke, Gilbert H Smith
Aug 14, 2013·Journal of Biosciences·Carlos Sonnenschein, Ana M Soto
May 26, 2010·Nature Reviews. Endocrinology·Ana M Soto, Carlos Sonnenschein
Dec 16, 2006·International Journal of Epidemiology·Volker Wunderlich
May 13, 2006·BMJ : British Medical Journal·Stuart G Baker, Jaakko Kaprio
Dec 13, 2005·Nephron. Experimental Nephrology·Peter J Nelson, Stuart J Shankland
Aug 9, 2007·BMC Cancer·Stuart G Baker, Barnett S Kramer
Aug 3, 2005·Cancer Cell International·Richmond T Prehn
Apr 28, 2005·Cancer Cell International·Richmond T Prehn
May 1, 2008·Cancer Cell International·Maricel V MaffiniTheoharis C Theoharides
Sep 26, 2013·Molecular Cancer·Prakash KulkarniRahul V Kulkarni
Feb 26, 2010·Nutrition & Metabolism·Thomas N Seyfried, Laura M Shelton
Jul 1, 2010·BMC Systems Biology·William J Bosl, Rong Li
Jun 16, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stuart G BakerJohn D Potter
Jun 9, 2009·Endocrine Reviews·Evanthia Diamanti-KandarakisAndrea C Gore
Apr 27, 2007·PloS One·Daniel StockholmAndras Paldi
Dec 15, 2012·Critical Reviews in Oncogenesis·Thomas N Seyfried, Leanne C Huysentruyt
Apr 9, 2010·Journal of Carcinogenesis·Sergey Rumyantsev
Dec 18, 2013·Carcinogenesis·Thomas N SeyfriedDominic P D'Agostino
Sep 8, 2012·Cellular and Molecular Life Sciences : CMLS·Andrei V Karotki, Keith Baverstock
Apr 14, 2011·Chemical Society Reviews·Maureen A Walling, Jason R E Shepard
Oct 13, 2009·Expert Review of Molecular Diagnostics·Charvonne HollidayRachel E Ellsworth
Jun 19, 2012·Clinical Epigenetics·Paike Jayadeva BhatAbhay Kumar
Jun 7, 2011·Seminars in Cancer Biology·Sui Huang
May 17, 2011·Seminars in Cancer Biology·C RossiS Lamponi
Mar 23, 2011·Progress in Biophysics and Molecular Biology·Stuart G Baker, Barnett S Kramer
Jan 24, 2009·Critical Reviews in Oncology/hematology·Anil K Panigrahi, Debananda Pati
Feb 14, 2006·The Journal of Investigative Dermatology·Ena WangFrancesco M Marincola
Oct 17, 2008·Cancer Letters·Emmanuel GarcionDidier Wion
May 13, 2008·Seminars in Cancer Biology·Carlos Sonnenschein, Ana M Soto
May 6, 2008·Seminars in Cancer Biology·Daniel Satgé, Jean Bénard
Jan 27, 2006·The American Journal of Pathology·Carlos Sonnenschein, Ana M Soto
Mar 17, 2005·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·James A Coffman

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